LEFT VENTRICULAR HYPERTROPHY IN TERMS OF SUDDEN CARDIAC DEATH

  • A.V. Barsukov LLC “KardioKlinika”. Kuznetsovskaya str., 25, Saint-Petersburg, Russian Federation, 196105
  • E.V. Borisova LLC “KardioKlinika”. Kuznetsovskaya str., 25, Saint-Petersburg, Russian Federation, 196105
  • M.S. Didenko LLC “KardioKlinika”. Kuznetsovskaya str., 25, Saint-Petersburg, Russian Federation, 196105
  • S.A. Glebova LLC “KardioKlinika”. Kuznetsovskaya str., 25, Saint-Petersburg, Russian Federation, 196105
  • A.V. Airapetyan LLC “KardioKlinika”. Kuznetsovskaya str., 25, Saint-Petersburg, Russian Federation, 196105
  • M.L. Ligidov LLC “KardioKlinika”. Kuznetsovskaya str., 25, Saint-Petersburg, Russian Federation, 196105
  • S.D. Rud Military Medical Academy named after S.M. Kirov. Akademician Lebedeva St., 6, Saint Petersburg, Russian Federation, 194044
  • E.I. Asaturova LLC “KardioKlinika”. Kuznetsovskaya str., 25, Saint-Petersburg, Russian Federation, 196105
  • I.I. Konovalova LLC “KardioKlinika”. Kuznetsovskaya str., 25, Saint-Petersburg, Russian Federation, 196105
DOI: https://doi.org/10.56871/MTP.2023.95.29.005
Keywords: sudden cardiac death; left ventricular hypertrophy; risk stratifi cation; ejection fraction; mechanism; subpopulation

Abstract

Sudden cardiac death (SCD) is one of the dominant causes of death in the modern world, which continues to be a serious medical and social problem for the healthcare system and society as a whole. The current risk stratification of patients in the aspect of primary prevention of SCD is based mainly on the left ventricular ejection fraction (LVEF), the value of which is 35 % or less is the decisive argument for the implantation of a cardioverter-defibrillator (ICD). However, this approach alone is accompanied by a relatively low frequency of ICD triggering to suppress life-threatening ventricular arrhythmias. The vast majority of patients who die suddenly have an LVEF > 35 % in vivo, which indicates the need for a better understanding of the mechanisms underlying SCD. Additional variables are important that, independently or in combination with low LVEF, may improve SCD prediction. Left ventricular hypertrophy (LVH) of any etiology is a strong
independent risk factor for SCD. Not only concentric and eccentric LVH variants, but also concentric LV remodeling without hypertrophy are associated with increased lethality. The article summarizes current ideas about the pathophysiology of LVH, provides a review of publications that reveal the mechanisms of the relationship between LVH and SCD in various subpopulations of cardiovascular patients. The value of LVH as a risk stratifier of sudden lethality is shown, regardless of the contractility of myocardium.

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Published
2024-03-15
How to Cite
Barsukov, A., Borisova, E., Didenko, M., Glebova, S., Airapetyan, A., Ligidov, M., Rud, S., Asaturova, E., & Konovalova, I. (2024). LEFT VENTRICULAR HYPERTROPHY IN TERMS OF SUDDEN CARDIAC DEATH. Medicine: Theory and Practice, 8(3), 44-59. https://doi.org/10.56871/MTP.2023.95.29.005
Issue
Vol 8 No 3 (2023)
Section
Статьи

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