PERSONALIZATION OF INTENSIVE NON-SURGICAL TREATMENT IN CHILDREN WITH SPLEEN INJURY
Abstract
Introduction. The main directions of intensive care in non-surgical treatment in children with trauma of the abdominal cavity organs are relevant and unresolved problems. The purpose of the study was to evaluate the effectiveness of the proposed infusion, analgesic and hemostatic therapy in non-operative treatment tactics in the first 24 hours after admission to the hospital in children with isolated spleen injury. Material and methods. 28 patients, from 6 to 12 years old, with trauma of the abdominal organs, who were treated at the Clinic for Pediatric Surgery. N.L. Kushcha on the basis of the Republican Children’s Clinical Hospital in Donetsk from 2014– 2023. The assessment of the severity and prognosis of mechanical injury was carried out on the basis of the pediatric trauma severity scale. Results. In the first 6 hours from the moment of admission to the hospital in patients with isolated blunt trauma, rupture of the spleen parenchyma, the severity of homeostasis disturbances corresponded to an average severe condition, characterized by moderate severe abdominal pain syndrome, class 1 blood loss (<15% BCC). Conclusion. The use on the first day of non-surgical treatment of a ketamine solution with infusion therapy with Ringer’s solution (10 ml/kg/hour) with a transition of 5 ml/kg/hour without the use of blood products is optimal for this group of patients. Hemostatic therapy with tranexamic acid is not accompanied by adverse reactions from the patient’s body associated with the pharmacodynamic effect of the drug.
References
Анастасов А.Г., Зубрилова Е.Г. Объективизация выбора лечебных мероприятий у детей с изолированным разрывом селезенки // Российский вестник детской хирургии, анестезиологии и реаниматологии. 2022; 12(2): 157–166. DOI: https://doi.org/10.17816/psaic1225.
American College of Surgeons Committee on Trauma. Advanced Trauma Life Support (ATLS) Student Course Manual, 10th ed, American College of Surgeons, Chicago, IL 2018.
Chidester S.J., Williams N., Wang W., Groner J.I. A pediatric massive transfusion protocol. J Trauma Acute Care Surg 2012; 73:1273.
Drucker N.A., Wang S.K., Newton C. Pediatric trauma-related coagulopathy: Balanced resuscitation, goal-directed therapy and viscoelastic assays. Semin Pediatr Surg 2019; 28:61.
Eckert M.J., Wertin T.M., Tyner S.D. et al. Tranexamic acid administration to pediatric trauma patients in a combat setting: the pediatric trauma and tranexamic acid study (PED-TRAX). J Trauma Acute Care Surg 2014; 77:852.
El-Menyar A., Sathian B., Asim M. et al. Efficacy of prehospital administration of tranexamic acid in trauma patients: A meta-analysis of the randomized controlled trials. Am J Emerg Med 2018; 36:1079.
Houston K.A., George E.C., Maitland K. Implications for paediatric shock management in resource-limited settings: a perspective from the FEAST trial. Critical Care (2018) 22:119 https://doi.org/10.1186/s13054-018-1966-4.
Kessler D.O. Abdominal Ultrasound for Pediatric Blunt Trauma: FAST Is Not Always Better. JAMA 2017; 317:2283.
Kornblith A.E., Addo N., Plasencia M. et al. Development of a Consensus-Based Definition of Focused Assessment With Sonography for Trauma in Children. JAMA Netw Open 2022; 5:e222922.
Lee L.K., Porter J.J., Mannix R. et al. Pediatric Traumatic Injury Emergency Department Visits and Management in US Children’s Hospitals From 2010 to 2019. Ann Emerg Med 2022; 79:279.
Maw G., Furyk C. Pediatric Massive Transfusion: A Systematic Review. Pediatr Emerg Care 2018; 34:594.
Myers S.R., Branas C.C., French B. et al. A National Analysis of Pediatric Trauma Care Utilization and Outcomes in the United States. Pediatr Emerg Care 2019; 35:1.
Netherton S., Milenkovic V., Taylor M., Davis P.J. Diagnostic accuracy of eFAST in the trauma patient: a systematic review and meta-analysis. CJEM 2019; 21:727.
Principi T., Schonfeld D., Weingarten L. et al. Update in Pediatric Emergency Medicine: Pediatric Resuscitation, Pediatric Sepsis, Interfacility Transport of the Pediatric Patient, Pain and sedation in the Emergency Department, Pediatric Trauma. Update Pediatr 2018; 17:223.
Recognition of shock. In: Pediatric Advanced Life Support Provider Manual, Chameides L, Samson RA, Schexnayder SM, Hazinski MF (Eds), American Heart Association, Dalls, TX 2016. P. 171.
Rosemary A. Kozar, Marie Crandall et.al. Organ injury scaling 2018 update: Spleen, liver, and kidney // J Trauma Acute Care Surg. 2018; 85(6): 1119-1122. DOI: 10.1097/TA.0000000000002058.
Seliverstov P.A., Shapkin Y.G. Assessment of severity and prognosis of polytrauma outcome: the current state of the problem (review). Sovremennye tehnologii v medicine. 2017; 9 (2): 207-218. https://doi.org/10.17691/stm2017.9.2.25.