MULTISYSTEM INFLAMMATORY SYNDROME IN ADULTS: HOW TO PROVE AND HOW TO TREAT IT?
Abstract
The pandemic of the new coronavirus disease has created serious threats to the physical health of the population and caused a wide range of complications. The multisystem inflammatory syndrome, which was previously detected in children and adolescents, and later found in adults, is considered. The article presents data on the prevalence, features of clinical manifestations, diagnosis, differential diagnosis and treatment of multisystem inflammatory syndrome in adults. The analysis of publications devoted to a series of cases, systematic reviews of cases of multisystem inflammatory syndrome in adults using eLIBRARY, Scopus, PubMed and Google Scholar.
References
Кантемирова М.Г., Новикова Ю.Ю., Овсянников Д.Ю. и др. Детский мультисистемный воспалительный синдром, ассоциированный с новой коронавирусной инфекцией (COVID-19): актуальная информация и клиническое наблюдение. Педиатрическая фармакология. 2020;17(3):219–229.
Методические рекомендации «Особенности течения Long-COVID-инфекции. Терапевтические и реабилитационные мероприятия». Терапия. 2022;1(Приложение):1–147.
Министерство здравоохранения России. Временные методические рекомендации по профилактике, диагностике и лечению новой коронавирусной инфекции (COVID-19). Версия 18 от 26.10.2023. Доступен по: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/064/609/original/ВМР_short_V18.pdf (дата обращения: 25.07.2024).
Потапенко В.Г., Потихонова Н.А., Байков В.В. и др. Вторичный гемофагоцитарный синдром у взрослых в клинической практике гематолога: обзор литературы и собственные данные. Клиническая онкогематология. 2015;8(2):169–184.
Amato M.K., Hennessy C., Shah K. et al. Multisystem inflammatory syndrome in an adult. J Emerg Med. 2021;61(1):1–3. DOI: 10.1016/j.jemermed.2021.02.007.
Atchessi N., Edjoc R., Striha M. et al. Epidemiologic and clinical characteristics of multisystem inflammatory syndrome in adults: a rapid review. Canada Communicable Disease Report. 2021;47(7-8):305–315. DOI: 10.14745/ccdr.v47i78a03.
Bastug A., Aslaner H., Aybar Bilir Y. et al. Multiple system inflammatory syndrome associated with SARS-CoV-2 infection in an adult and an adolescent. Rheumatology International. 2021;41(5):993–1008. DOI: 10.1007/s00296-021-04843-1.
Belay E.D., Abrams J., Oster M.E. et al. Trends in geographic and temporal distribution of US children with multisystem inflammatory syndrome during the COVID-19 pandemic. JAMA Pediatrics. 2021;175(8):837–845.
Belhadjer Z., Méot M., Bajolle F. et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. 2020;142(5):429–436. DOI: 10.1161/CIRCULATIONAHA.120.048360.
Carvalho V., Damasco P.H., Mello T.S. et al. Para-aortic lymphadenopathy associated with adult COVID-19 multisystem inflammatory syndrome. BMJ Case Rep. 2021;14(12):246884. DOI: 10.1136/bcr-2021-246884.
Costa A.E., Bernasconi N.S., Trendelenburg M. et al. Severe myopathy complicating multisystem inflammatory syndrome in adults (MIS-A) in a young man. BMJ Case Reports CP. 2022;15:250054. DOI: 10.1136/bcr-2022-250054.
DeBiasi R.L., Song X., Delaney M. et al. Severe coronavirus disease-2019 in children and young adults in the Washington, DC, Metropolitan Region. J. Pediatr. 2020;223:199–203. DOI: 10.1016/j.jpeds.2020.05.007.
DeCuir J., Baggs J., Melgar M. et al. Identification and description of patients with multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection using the Premier Healthcare Database. Epidemiology and Infection. 2022;150:26. DOI: 10.1017/s0950268822000024.
Downing S., Chauhan V., Chaudry I.H. et al. Colchicine, Aspirin, and Montelukast — A Case of Successful Combined Pharmacotherapy for Adult Multisystem Inflammatory Syndrome in COVID-19. J Glob Infect Dis. 2020;12(4):221–224. DOI: 10.4103/jgid.jgid_296_20.
Farooqi K.M., Chan A., Weller R.J. et al. Longitudinal Outcomes for Multisystem Inflammatory Syndrome in Children. Pediatrics. 2021;148(2):e2021051155. DOI: 10.1542/peds.2021-051155.
Feldstein L.R., Tenforde M.W., Friedman K.G. et al. Characteristics and Outcomes of US Children and Adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) Compared with Severe Acute COVID-19. JAMA. 2021;325(11):1074–1087. DOI: 10.1001/jama.2021.2091.
Gurin M.I., Lin Y.J., Bernard S. et al. Cardiogenic shock complicating multisystem inflammatory syndrome following COVID-19 infection: a case report. BMC Cardiovasc Disord. 2021;21(1):522. DOI: 10.1186/s12872-021-02304-y.
Henderson L.A., Canna S.W., Friedman K.G. et al. American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 3. Arthritis Rheumatol. 2022;74(4):1–20. DOI: 10.1002/art.42062.
Hookham L., Fisher C., Manson J.J. et al. Understanding the diagnosis and management of multisystem inflammatory syndrome in adults (MIS-A) in the UK: results of a national Delphi process. Clinical Medicine (London, England). 2022;22(3):266–270. DOI: 10.7861/clinmed.2021-0700.
Hosseini P., Fallahi M.S., Erabi G. et al. Multisystem Inflammatory Syndrome and Autoimmune Diseases Following COVID-19: Molecular Mechanisms and Therapeutic Opportunities. Front Mol Biosci. 2022;9:804109. DOI: 10.3389/fmolb.2022.804109.
Jones V.G., Mills M., Suarez D. et al. COVID-19 and Kawasaki disease: Novel virus and novel case. Hosp Pediatr. 2020;10(6):537–540. DOI: 10.1542/hpeds.2020-0123.
Kumar M.A., Krishnaswamy M., Arul J.N. Post COVID-19 sequelae: Venous thromboembolism complicated by lower GI bleed. BMJ Case Rep. 2021;14(1):241059. DOI: 10.1136/bcr-2020-241059.
Kunal S., Ish P., Sakthivel P. et al. The emerging threat of multisystem inflammatory syndrome in adults (MIS-A) in COVID-19: A systematic review. Heart Lung. 2022;54:7–18. DOI: 10.1016/j.hrtlng.2022.03.007.
McCrindle B.W., Rowley A.H., Newburger J.W. et al. Diagnosis, treatment, and long-term management of Kawasaki disease: A scientific statement for health professionals from the American Heart Association. Circulation. 2017;135(17):927–999. DOI: 10.1161/CIR.0000000000000703.
Mittal N., Abohelwa M., Brogan J. et al. A case report of multisystem inflammatory syndrome in adults (MIS-A) associated with heart failure. Eur Heart J Case Rep. 2021;5(10):381. DOI: 10.1093/ehjcr/ytab381.
Morris S.B., Schwartz N.G., Patel P. et al. Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection — United Kingdom and United States, March–August 2020. MMWR Morb Mortal Wkly Rep. 2020;69(40):1450–1456. DOI: 10.15585/mmwr.mm6940e1.
Multisystem inflammatory syndrome in adults (MIS-A) case definition information for healthcare providers. Centers for Disease Control and Prevention. Доступен по: https://www.cdc.gov/mis/hcp/case-definition-reporting (дата обращения: 25.07.2024).
Nawfal O., Toufaili H., Dib G. et al. New-onset refractory status epilepticus as an early manifestation of multisystem inflammatory syndrome in adults after COVID-19. Epilepsia. 2022;63(5):51–56. DOI: 10.1111/epi.17231.
Parums D.V. Editorial: Multisystem Inflammatory Syndrome in Adults (MIS-A) and the Spectrum of COVID-19. Med Sci Monit. 2021;27:935005. DOI: 10.12659/MSM.935005.
Patel P., DeCuir J., Abrams J. et al. Clinical characteristics of multisystem inflammatory syndrome in adults: A systematic review. JAMA Netw. Open. 2021;4(9):2126456. DOI: 10.1001/jamanetworkopen.2021.26456.
Qamar M.A., Afzal S.S., Dhillon R.A. et al. A global systematic review and meta-analysis on the emerging evidence on risk factors, clinical characteristics, and prognosis of multisystem inflammatory syndrome in adults (MIS-A). Annals of Medicine and Surgery. 2023;85(9):4463–4475. DOI: 10.1097/ms9.0000000000000732.
Riphagen S., Gomez X., Gonzalez-Martinez C. et al. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395(10237):1607–1608.
Schultz J.C., Hilliard A.A., Cooper L.T. Jr. et al. Diagnosis and treatment of viral myocarditis. Mayo Clin Proc. 2009;84(11):1001–9. DOI: 10.1016/S0025-6196(11)60670-8.
Shen M., Milner A., Foppiano Palacios C. et al. Multisystem inflammatory syndrome in adults (MIS-A) associated with SARS-CoV-2 infection with delayed-onset myocarditis: case report. Eur Heart J Case Rep. 2021;5:470. DOI: 10.1093/ehjcr/ytab470.
Stratton C.W., Tang Y.W., Lu H. Pathogenesis-directed therapy of 2019 novel coronavirus disease. J Med Virol. 2021;93:1320–1342. DOI: 10.1002/ jmv.26610.
Tahaghoghi-Hajghorbani S., Zafari P., Masoumi E. et al. The role of dysregulated immune responses in COVID-19 pathogenesis. Virus Res. 2020;290:198197. DOI: 10.1016/j.virusres.2020.198197.
Townsend L., Fogarty H., Dyer A. et al. Prolonged elevation of D-dimer levels in convalescent COVID-19 patients is independent of the acute phase response. J. Thromb Haemost. 2021;19(4):1064–1070. DOI: 10.1111/jth.15267.
Vogel T.P., Top K.A., Karatzios C. et al. Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2021;39(22):3037–3049. DOI: 10.1016/j.vaccine.2021.01.054.
Vujaklija Brajković A., Zlopaša O., Gubarev Vrdoljak N. et al. Acute liver and cardiac failure in multisystem inflammatory syndrome in adults after COVID-19. Clinics and Research in Hepatology and Gastroenterology. 2021;45(3):101678. DOI: 10.1016/j.clinre.2021.101678.
Weatherhead J.E., Clark E., Vogel T.P. et al. Inflammatory syndromes associated with SARS-CoV-2 infection: dysregulation of the immune response across the age spectrum. J. Clin Invest. 2020;130(12):6194–6197. DOI: 10.1172/JCI145301.
Weisberg S.P., Connors T.J., Zhu Y. et al. Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum. Nat Immunol. 2021;22(1):25–31. DOI: 10.1038/s41590-020-00826-9.
World Health Organization. Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19. May 15, 2020. Доступен по: https://www.who.int/ news-room/commentaries/detail/multisystem-inflammatory-syndrome-in-childrenand-adolescents-with-covid-19 (дата обращения: 09.11.2023).
Yamada Y., Fujinami K., Eguchi T. et al. Multisystem Inflammatory Syndrome in Adults after Mild SARS-CoV-2 Infection, Japan. Emerging Infectious Diseases. 2021;27(6):1740–1742. DOI: 10.3201/eid2706.210728.
