POSSIBILITIES OF COMPUTED TOMOGRAPHY IN ASSESSING THE TREATMENT OF LYMPHANGIOLEIOMYOMATOSIS (LAM) (CLINICAL OBSERVATION)

Abstract

Assessment of the course of the disease and the results of treatment in LAM is carried out using computed tomography. The most common form of manifestation of the disease and its complicated course is the development of spontaneous pneumothorax. Its treatment — surgical intervention (Bulau drainage) can cause a cascade of rupture of the following air-containing cysts and is not safe for patients. Options for its drug prevention and treatment, including with the help of inhibitors i-mTOR, are being considered. Materials and methods. Retrospective analysis of computed tomography data (7) with dynamic observation of the course of the disease in a LAMA patient with recurrent pneumothorax without and against the background of treatment with i-mTOR inhibitors. Results. clinical observation of the effective use of sirolimus in a patient with recurrent pneumothorax (7 times). Conclusion. The experience of using i-mTOR inhibitors in a LAMA patient with recurrent pneumothorax suggests their therapeutic effect not only on extra-thoracic neoplasms and chyletic effusion, but also on cystic transformation of lung tissue (its stabilization, absence of complications by spontaneous pneumothorax).