ПАТОЛОГИЯ ПАРОДОНТА И АРТЕРИАЛЬНАЯ ГИПЕРТЕНЗИЯ
Аннотация
Воспалительные заболевания пародонта часто ассоциированы с артериальной гипертензией (АГ), и вопрос причинно-следственной связи этой коморбидности остается предметом дискуссии. Хронический пародонтит и АГ имеют общие факторы риска. Наличие пародонтопатогенной микрофлоры и действие эндотоксинов, способных вызывать системные, воспалительные и иммунные реакции, метаболическое липидное поражение тканей, нарушать гемостаз, рассматривают принципиальными общими патогенетическими механизмами развития как пародонтита, так и АГ. В обзоре представлены данные, доказывающие взаимосвязь этих заболеваний.
Литература
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Albush M.M., Razan K.K., Al Dieri M.R. Effect of surgical and non-surgical periodontal debridement on vascular thrombotic markers in hypertensives. J Indian Soc Periodontol. 2013; 17: 324.
Bhola P.D., Letai A. Mitochondria-Judges and Executioners of Cell Death Sentences Mol Cell. 2016; 61(5): 695–704.
Bonato C., do-Amaral C., Belini L. et al. Hypertension favors the inflammatory process in rats with experimentally induced periodontitis. J Periodontal Res. 2012; 47: 783-92.
Cheung B.M., Li C. Diabetes and hypertension: is there a common metabolic pathway? Curr Atheroscler Rep. 2012; 14: 160–6.
Choi H.M., Han K., Park Y.G., Park J.B. Associations Among Oral Hygiene Behavior and Hypertension Prevalence and Control: The 2008–2010 Korea National Health and Nutrition Examination Survey. J Periodontol. 2015: 1–19.
Czesnikiewicz-Guzik M., Nosalski R., Mikolajczyk T.P. et al. Th1-type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II-dependent hypertension and vascular dysfunction. Br J Pharmacol. 2019; 176: 1922–31.
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Demmer R.T., Papapanou P.N., Jacobs DR. Jr., Desvarieux M. Bleeding on probing differ-entially relates to bacterial profiles: the oral infections and vascular disease epidemiology study. J Clin Periodontol. 2008; 35: 479–48.
Luo Y., Ye H., Liu W. et al. Effect of periodontal treatments on blood pressure. Cochrane Database Syst Rev. 2021; 12(12): CD009409. DOI: 10.1002/14651858.CD009409.pub2.
Febbraio M. Is There a Causal Link Between Periodontitis and Cardiovascular Disease? A Concise Review of Recent Findings. International Dental Journal. 2022; 72(1): 37–51.
Graziani F., Cei S., Tonetti M. et al. Systemic inflammation following non-surgical and surgical periodontal therapy. J Clin Periodontol. 2010; 37: 848.
Guzik T.J., Skiba D.S., Touyz R.M., Harrison D.G. The role of infiltrating immune cells in dysfunctional adipose tissue. Cardiovasc Res. 2017; 113: 1009–23.
Kawabata Y., Ekuni D., Miyai H. et al. Relationship between prehypertension/hypertension and periodontal disease: a prospective cohort study. Am J Hypertens. 2016; 29: 388–96.
Khocht A., Rogers T., Janal M., Brown M. Gingival fluid inflammatory biomarkers and hypertension in African Americans. JDR Clin Trans Res. 2017; 2: 269–77.
Lee J-H., Oh J-Y., Youk T-M. et al. Association between periodontal disease and non-communicable diseases: a 12-year longitudinal healthexaminee cohort study in South Korea. Medicine. 2017; 96: e7398.
Leong X.F., Ng C.Y., Badiah B., Das S. Association between hypertension and periodontitis: possible mechanisms. Scientific World Journal. 2014; 2014: 768237.
Lewington S., Clarke R., Qizilbash N. et al. Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002; 360: 1903–13.
Luo Y., Ye H., Liu W. et al. Effect of periodontal treatments on blood pressure. Cochrane Database Syst Rev. 2021; 12(12): CD009409. DOI: 10.1002/14651858.CD009409.pub2. PMID: 34897644.
Sanz M., Marco Del Castillo A., Jepsen S. Periodontitis and Cardiovascular Diseases. Consensus Report. J Clin Periodontol. 2020; 47: 268–88.
Zhao M., Qiao Yi, Wu Lan, et al. Periodontal Disease Is Associated With Increased Risk of Hypertension: A Cross-Sectional Study Medicine Front. Physiol. 2019; 10: 440 DOI:10.3389/fphys.2019.00440.
Martin-Cabezas R., Seelam N., Petit C. et al. Association between periodontitis and arterial hypertension: a systematic review and meta-analysis. Am Heart J. 2016; 180: 98–112.
Masiha S. Inflammatory markers are associated with left ventricular hypertrophy and diastolic dysfunction in a population-based sample of elderly men and women. J Hum Hypertens. 2013; 27(1): 13–7.
Mikolajczyk T.P., Nosalski R., Szczepaniak P. et al. Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension. FASEB J. 2016; 30: 1987–99.
Missing teeth predict incident cardiovascular events, diabetes, and death. J Dent Res. 2015; 94: 1055–62.
Morita T., Yamazaki Y., Fujiharu C. et al. Association between the duration of periodontitis and increased cardiometabolic risk factors: a 9-year cohort study. Metab Syndr Relat Disord. 2016; 14: 475–82.
Morita T., Yamazaki Y., Mita A. et al. A cohort study on the association between periodontal disease and the development of metabolic syndrome. J Periodontol. 2010; 81: 512–9.
Munoz Aguilera E., Suvan J., Buti J. et al. Periodontitis is associated with hypertension: a systematic review and meta-analysis. Cardiovasc Res. 2020; 116: 28–39.
Munoz Aguilera E., Suvan J., Buti J. et al. Periodontitis is associated with hypertension: a systematic review and meta-analysis. Cardiovasc Res. 2020; 116: 28–39.
Paffen E. C-reactive protein in atherosclerosis: A causal factor? Cardiovasc. res. 2006; 71: 30–9.
Pedrrinelli R. Low-grade inflammation and microalbuminuria in hypertension, arteriosclerosis. Thromb. vasc. biol. 2004; 24: 2414–9.
Rutter M.K. C-Reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the framingham offspring study. Circulation. 2004; 110(4): 380–5.
Taylor B., Tofler G., Morel-Kopp M-C. et al. The effect of initial treatment of periodontitis on systemic markers of inflammation and cardiovascular risk: a randomized controlled trial. Eur J Oral Sci. 2010; 118: 350.
Tonetti M.S., Dyke T.E. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013; 40: S24.
Tsioufis C., Kasiakogias A., Thomopoulos C., Stefanadis C. Periodontitis and blood pressure: the concept of dental hypertension. Atherosclerosis. 2011; 219: 1–9.
Türkoğlu O., Barıs N., Tervahartiala T. et al. Evaluation of systemic levels of neutrophilic enzymes in patients with hypertension and chronic periodontitis. J Periodontol. 2014; 85: 908–16.
Watatnabe T. et al. Carotid artery intima-media thickness and reactive oxygen species in hypertensive patients. J. hum. hypertens. 2006; 20: 336–40.
Zhou Q-B., Xia W-H., Ren J. et al. Effect of intensive periodontal therapy on blood pressure and endothelial microparticles in patients with prehypertension and periodontitis: a randomized controlled trial. J Periodontol. 2017; 88: 711–22.
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Bhola P.D., Letai A. Mitochondria-Judges and Executioners of Cell Death Sentences Mol Cell. 2016; 61(5): 695–704.
Bonato C., do-Amaral C., Belini L. et al. Hypertension favors the inflammatory process in rats with experimentally induced periodontitis. J Periodontal Res. 2012; 47: 783-92.
Cheung B.M., Li C. Diabetes and hypertension: is there a common metabolic pathway? Curr Atheroscler Rep. 2012; 14: 160–6.
Choi H.M., Han K., Park Y.G., Park J.B. Associations Among Oral Hygiene Behavior and Hypertension Prevalence and Control: The 2008–2010 Korea National Health and Nutrition Examination Survey. J Periodontol. 2015: 1–19.
Czesnikiewicz-Guzik M., Nosalski R., Mikolajczyk T.P. et al. Th1-type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II-dependent hypertension and vascular dysfunction. Br J Pharmacol. 2019; 176: 1922–31.
D’Aiuto F., Gkranias N., Bhowruth D. et al. Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial. Lancet Diabetes Endocrinol. 2018; 6: 954–65.
Demmer R.T., Papapanou P.N., Jacobs DR. Jr., Desvarieux M. Bleeding on probing differ-entially relates to bacterial profiles: the oral infections and vascular disease epidemiology study. J Clin Periodontol. 2008; 35: 479–48.
Luo Y., Ye H., Liu W. et al. Effect of periodontal treatments on blood pressure. Cochrane Database Syst Rev. 2021; 12(12): CD009409. DOI: 10.1002/14651858.CD009409.pub2.
Febbraio M. Is There a Causal Link Between Periodontitis and Cardiovascular Disease? A Concise Review of Recent Findings. International Dental Journal. 2022; 72(1): 37–51.
Graziani F., Cei S., Tonetti M. et al. Systemic inflammation following non-surgical and surgical periodontal therapy. J Clin Periodontol. 2010; 37: 848.
Guzik T.J., Skiba D.S., Touyz R.M., Harrison D.G. The role of infiltrating immune cells in dysfunctional adipose tissue. Cardiovasc Res. 2017; 113: 1009–23.
Kawabata Y., Ekuni D., Miyai H. et al. Relationship between prehypertension/hypertension and periodontal disease: a prospective cohort study. Am J Hypertens. 2016; 29: 388–96.
Khocht A., Rogers T., Janal M., Brown M. Gingival fluid inflammatory biomarkers and hypertension in African Americans. JDR Clin Trans Res. 2017; 2: 269–77.
Lee J-H., Oh J-Y., Youk T-M. et al. Association between periodontal disease and non-communicable diseases: a 12-year longitudinal healthexaminee cohort study in South Korea. Medicine. 2017; 96: e7398.
Leong X.F., Ng C.Y., Badiah B., Das S. Association between hypertension and periodontitis: possible mechanisms. Scientific World Journal. 2014; 2014: 768237.
Lewington S., Clarke R., Qizilbash N. et al. Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002; 360: 1903–13.
Luo Y., Ye H., Liu W. et al. Effect of periodontal treatments on blood pressure. Cochrane Database Syst Rev. 2021; 12(12): CD009409. DOI: 10.1002/14651858.CD009409.pub2.PMID: 34897644.
Sanz M., Marco Del Castillo A., Jepsen S. Periodontitis and Cardiovascular Diseases. Consensus Report. J Clin Periodontol. 2020; 47: 268–88.
Zhao M., Qiao Yi, Wu Lan, et al. Periodontal Disease Is Associated With Increased Risk of Hypertension: A Cross-Sectional Study Medicine Front. Physiol. 2019; 10: 440 DOI:10.3389/fphys.2019.00440.
Martin-Cabezas R., Seelam N., Petit C. et al. Association between periodontitis and arterial hypertension: a systematic review and meta-analysis. Am Heart J. 2016; 180: 98–112.
Masiha S. Inflammatory markers are associated with left ventricular hypertrophy and diastolic dysfunction in a population-based sample of elderly men and women. J Hum Hypertens. 2013; 27(1): 13–7.
Mikolajczyk T.P., Nosalski R., Szczepaniak P. et al. Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension. FASEB J. 2016; 30: 1987–99.
Missing teeth predict incident cardiovascular events, diabetes, and death. J Dent Res. 2015; 94: 1055–62.
Morita T., Yamazaki Y., Fujiharu C. et al. Association between the duration of periodontitis and increased cardiometabolic risk factors: a 9-year cohort study. Metab Syndr Relat Disord. 2016; 14: 475–82.
Morita T., Yamazaki Y., Mita A. et al. A cohort study on the association between periodontal disease and the development of metabolic syndrome. J Periodontol. 2010; 81: 512–9.
Munoz Aguilera E., Suvan J., Buti J. et al. Periodontitis is associated with hypertension: a systematic review and meta-analysis. Cardiovasc Res. 2020; 116: 28–39.
Munoz Aguilera E., Suvan J., Buti J. et al. Periodontitis is associated with hypertension: a systematic review and meta-analysis. Cardiovasc Res. 2020; 116: 28–39.
Paffen E. C-reactive protein in atherosclerosis: A causal factor? Cardiovasc. res. 2006; 71: 30–9.
Pedrrinelli R. Low-grade inflammation and microalbuminuria in hypertension, arteriosclerosis. Thromb. vasc. biol. 2004; 24: 2414–9.
Rutter M.K. C-Reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the framingham offspring study. Circulation. 2004; 110(4): 380–5.
Taylor B., Tofler G., Morel-Kopp M-C. et al. The effect of initial treatment of periodontitis on systemic markers of inflammation and cardiovascular risk: a randomized controlled trial. Eur J Oral Sci. 2010; 118: 350.
Tonetti M.S., Dyke T.E. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013; 40: S24.
Tsioufis C., Kasiakogias A., Thomopoulos C., Stefanadis C. Periodontitis and blood pressure: the concept of dental hypertension. Atherosclerosis. 2011; 219: 1–9.
Türkoğlu O., Barıs N., Tervahartiala T. et al. Evaluation of systemic levels of neutrophilic enzymes in patients with hypertension and chronic periodontitis. J Periodontol. 2014; 85: 908–16.
Watatnabe T. et al. Carotid artery intima-media thickness and reactive oxygen species in hypertensive patients. J. hum. hypertens. 2006; 20: 336–40.
Zhou Q-B., Xia W-H., Ren J. et al. Effect of intensive periodontal therapy on blood pressure and endothelial microparticles in patients with prehypertension and periodontitis: a randomized controlled trial. J Periodontol. 2017; 88: 711–22.
