ХАРАКТЕРИСТИКА ХОНДРОПЛАСТИЧЕСКИХ МАТЕРИАЛОВ: ПРЕИМУЩЕСТВА И НЕДОСТАТКИ

Юрий Алексеевич Новосад; Полина Андреевна Першина; Марат Сергеевич Асадулаев; Антон Сергеевич Шабунин; Ирина Сергеевна Чустрак; Вероника Владимировна Траксова; Александра Сергеевна Байдикова; Евгений Владимирович Зиновьев; Сергей Валентинович Виссарионов

doi:10.56871/RBR.2023.19.73.005

Юрий Алексеевич Новосад Национальный медицинский исследовательский центр детской травматологии и ортопедии им. Г.И. Турнера. 196603, г. Санкт-Петербург, г. Пушкин, ул. Парковая, 64–68 https://orcid.org/0000-0002-6150-374X
Полина Андреевна Першина Национальный медицинский исследовательский центр детской травматологии и ортопедии им. Г.И. Турнера. 196603, г. Санкт-Петербург, г. Пушкин, ул. Парковая, 64–68
Марат Сергеевич Асадулаев Национальный медицинский исследовательский центр детской травматологии и ортопедии им. Г.И. Турнера. 196603, г. Санкт-Петербург, г. Пушкин, ул. Парковая, 64–68
Антон Сергеевич Шабунин Национальный медицинский исследовательский центр детской травматологии и ортопедии им. Г.И. Турнера. 196603, г. Санкт-Петербург, г. Пушкин, ул. Парковая, 64–68
Ирина Сергеевна Чустрак Санкт-Петербургский государственный педиатрический медицинский университет. 194100, Российская Федерация, г. Санкт-Петербург, ул. Литовская, д. 2
Вероника Владимировна Траксова Санкт-Петербургский государственный педиатрический медицинский университет. 194100, Российская Федерация, г. Санкт-Петербург, ул. Литовская, д. 2
Александра Сергеевна Байдикова Санкт-Петербургский государственный педиатрический медицинский университет. 194100, Российская Федерация, г. Санкт-Петербург, ул. Литовская, д. 2
Евгений Владимирович Зиновьев Санкт-Петербургский государственный педиатрический медицинский университет. 194100, Российская Федерация, г. Санкт-Петербург, ул. Литовская, д. 2
Сергей Валентинович Виссарионов Национальный медицинский исследовательский центр детской травматологии и ортопедии им. Г.И. Турнера. 196603, г. Санкт-Петербург, г. Пушкин, ул. Парковая, 64–68

DOI: https://doi.org/10.56871/RBR.2023.19.73.005

Ключевые слова: хондропластика, тканевая инженерия, биологические полимеры, хондроциты

Аннотация

Введение. Суставной хрящ, ввиду особенностей своего строения и отсутствия активной трофики, не способен к самостоятельной регенерации. Существующие клинические методы восстановления хрящевой ткани имеют множество ограничений, из-за чего разработка тканеинженерных конструкций остается актуальной задачей в области медицины, биологии и материаловедения. Цель исследования: провести анализ существующих материалов для хондропластики и выявить их преимущества и недостатки. Материалы и методы. Дизайн исследования представлен несистематическим обзором литературы. Поиск данных осуществляли в базах данных PubMed, ScienceDirect, eLibrary, Google Scholar. Глубина поиска составила 15 лет, большинство работ, включенных в исследование, опубликованы в последние 5 лет. Критерии включения работ: наличие полного текста рукописи, наличие гистологических исследований, статистического анализа данных. Критериями исключения работ считали: поглощающий характер статей одного автора (в анализ включали более позднюю публикацию). Результаты исследования. В ходе работы было установлено, что в разработке хондропластических материалов применяются как биологические, так и синтетические полимеры. Биологические полимеры обладают высоким сродством к культурам клеток, при этом не способны выдерживать значительные механические нагрузки. Решением проблемы механической прочности является применение синтетических полимеров. В качестве основной культуры клеток, которая влияет на ускорение восстановления дефекта, используются хондроциты. Активное применение находят также дифференцировочные факторы, в особенности факторы из числа костных морфогенетических белков (BMP).
Заключение. И природные биополимеры, и синтетические полимеры имеют как преимущества, так и недостатки, что приводит к необходимости применения разных типов полимеров для обеспечения мимикрических свойств разрабатываемых конструкций. Применение факторов роста, факторов дифференцировки, клеточных культур и биологически активных веществ способствует ускорению процессов регенерации.

Литература

Айтназаров Р.Б. и др. Идентификация полноразмерных геномов эндогенных ретровирусов у сибирских мини-свиней. Вавиловский журнал генетики и селекции. 2014; 2(18): 294–9.

Зазирный И.М., Шмигельски Р.Я. Трансплантация мениска коленного сустава: современное состояние проблемы. Обзор литературы. Травма. 2015; 6(16): 81–95.

Закирова А.Р., Королев А.В., Загородний Н.В. Эффективная тактика хирургического лечения при восстановлении суставного хряща коленного сустава. 2017.

Кумачный А.Л., Москаленко И.С., Шульгов Ю.И. Способы и методы лечения болезни Осгуда–Шляттера с помощью оздоровительной физкультуры. Символ науки. 2017; (06): 113–7.

Лазишвили Г.Д. Гибридная костно-хрящевая трансплантация — новый способ хирургического лечения рассекающего остеохондрита коленного сустава. Травматология и ортопедия. 2019; 25: 13–8.

Сабурина И.Н. и др. Перспективы и проблемы применения культур клеток для регенеративной медицины. Патогенез. 2015; 1(13): 60–73.

Abeer M.M., Mohd Amin M.C.I., Martin C. A review of bacterial cellulose-based drug delivery systems: Their biochemistry, current approaches and future prospects. Journal of Pharmacy and Pharmacology. 2014; 66(8): 1047–61.

Azizian S., Hadjizadeh A., Niknejad H. Chitosan-gelatin porous scaffold incorporated with Chitosan nanoparticles for growth factor delivery in tissue engineering. Carbohydrate Polymers. 2018; 202: 315–22.

Bauer M., Jackson R.W. Chondral Lesions of the Femoral Condyles: Arthroscopic Classification A System of. 1988.

Beer A.J. et al. Use of Allografts in Orthopaedic Surgery: Safety, Procurement, Storage, and Outcomes. Orthopaedic Journal of Sports Medicine. 2019; 7(12).

Bertuola M. et al. Gelatin–alginate–hyaluronic acid inks for 3D printing: effects of bioglass addition on printability, rheology and scaffold tensile modulus. Journal of Materials Science. 2021; 27(56): 15327–43.

Bidarra S.J., Barrias C.C., Granja P.L. Injectable alginate hydrogels for cell delivery in tissue engineering. Acta Biomaterialia. 2014; 10(4): 1646–62.

Bingül N.D. и др. Microbial biopolymers in articular cartilage tissue engineering. Journal of Polymer Research. 2022; 29(8).

Boushell M.K. et al. Current strategies for integrative cartilage repair. Connective Tissue Research. 2017; 58(5): 393–406.

Chau M. et al. Osteochondritis dissecans: current understanding of epidemiology, etiology, management, and outcomes. ncbi.nlm.nih.gov.

Cheng A. et al. Advances in Porous Scaffold Design for Bone and Cartilage Tissue Engineering and Regeneration. Tissue Engineering — Part B: Reviews. 2019; 25(1): 14–29.

Cheng H. et al. Hierarchically Self-Assembled Supramolecular Host-Guest Delivery System for Drug Resistant Cancer Therapy. Biomacromolecules. 2018; 6(19): 1926–38.

Deepthi S. et al. An overview of chitin or chitosan/nano ceramic composite scaffolds for bone tissue engineering. International Journal of Biological Macromolecules. 2016; 93: 1338–53.

Dhillon J. et al. Third-Generation Autologous Chondrocyte Implantation (Cells Cultured Within Collagen Membrane) Is Superior to Microfracture for Focal Chondral Defects of the Knee Joint: Systematic Review and Meta-analysis. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2022; 8(38): 2579–86.

Fan L. et al. Value of 3D Printed PLGA Scaffolds for Cartilage Defects in Terms of Repair. Evidence-based Complementary and Alternative Medicine. 2022; 2022.

Farokhi M. et al. Alginate Based Scaffolds for Cartilage Tissue Engineering: A Review. International Journal of Polymeric Materials and Polymeric Biomaterials. 2020; 4(69): 230–47.

Farsi M., Asefnejad A., Baharifar H. A hyaluronic acid/PVA electrospun coating on 3D printed PLA scaffold for orthopedic application. Progress in Biomaterials. 2022; 1(11): 67–77.

Gao L. et al. Effects of genipin cross-linking of chitosan hydrogels on cellular adhesion and viability. Colloids and Surfaces B: Biointerfaces. 2014; 117: 398–405.

Giovanni A.M., Greta Ph.E.D., Frank P.L. Donor site morbidity after articular cartilage repair procedures: A review. Acta orthopaedica Belgica. 2010; 76: 669–74.

Gonzalez-Fernandez T. et al. Gene Delivery of TGF-β3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering. Tissue Engineering — Part A. 2016; 9–10(22): 776–87.

Gorenkova N. et al. The innate immune response of self-assembling silk fibroin hydrogels. Biomaterials Science. 2021; 21(9): 7194–204.

Gui X. et al. 3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction. Bio-Design and Manufacturing. 2023.

Guo J.L. et al. Modular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineering. Science Advances. 2019; 5: 1–11.

Haaparanta A.M. et al. Preparation and characterization of collagen/PLA, chitosan/PLA, and collagen/chitosan/PLA hybrid scaffolds for cartilage tissue engineering. Journal of Materials Science: Materials in Medicine. 2014; 4(25): 1129–36.

Hanifi A. et al. Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties. Analyst. 2017; 8(142): 1320–32.

Helfer E. et al. Vascular grafts collagen coating resorption and

hea ling process in humans. JVS-Vascular Science. 2022; 3: 193–204.

Hu T., Lo A.C.Y. Collagen–alginate composite hydrogel: Application in tissue engineering and biomedical sciences. Polymers. 2021; 11(13).

Hu X. et al. Recent progress in 3D printing degradable poly-

actic acid-based bone repair scaffold for the application of cancellous bone defect. MedComm — Biomaterials and Applications. 2022; 1(1).

Hunziker E.B., Quinn T.M., Häuselmann H.J. Quantitative structural organization of normal adult human articular cartilage. Osteoarthritis and Cartilage. 2002; 7(10): 564–72.

Intini C. et al. A highly porous type II collagen containing scaffold for the treatment of cartilage defects enhances MSC chondrogenesis and early cartilaginous matrix deposition. Biomaterials Science. 2022; 4(10): 970–83.

Jahn S., Seror J., Klein J. Lubrication of Articular Cartilage. Annual Review of Biomedical Engineering. 2016; 18: 235–58.

Koh L.D. et al. Structures, mechanical properties and applications of silk fibroin materials. Progress in Polymer Science. 2015; 46: 86–110.

Kuboyama N. et al. Silk fibroin-based scaffolds for bone regeneration. Journal of Biomedical Materials Research — Part B Applied Biomaterials. 2013; 2(101 B): 295–302.

Kundu J. et al. An additive manufacturing-based PCL-alginate-chondrocyte bioprinted scaffold for cartilage tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. 2015; 11(9): 1286–97.

Lam A.T.L., Reuveny S., Oh S.K.W. Human mesenchymal stem cell therapy for cartilage repair: Review on isolation, expansion, and constructs. Stem Cell Research. 2020; (44).

Lednev I. et al. Development of biodegradable polymer blends based on chitosan and polylactide and study of their properties. Materials. 2021; 17(14).

Li Z. et al. Biodegradable silica rubber core-shell nanoparticles and their stereocomplex for efficient PLA toughening. Composites Science and Technology. 2018; 159: 11–7.

Lin C. H. et al. Stiffness modification of photopolymerizable gelatin-methacrylate hydrogels influences endothelial differentiation of human mesenchymal stem cells. Journal of Tissue Engineering and Regenerative Medicine. 2018; 10(12): 2099–2111.

Lin Z. et al. The Chondrocyte: Biology and Clinical Application. Tissue engineering. 2006; 7(12): 1971–88.

Lind M. et al. Cartilage repair with chondrocytes in fibrin hydrogel and MPEG polylactide scaffold: An in vivo study in goats. Knee Surgery, Sports Traumatology, Arthroscopy. 2008; 7(16): 690–8.

Lu Y. et al. Solubilized Cartilage ECM Facilitates the Recruitment and Chondrogenesis of Endogenous BMSCs in Collagen Scaffolds for Enhancing Microfracture Treatment. ACS Applied Materials and Interfaces. 2021.

Ma D., Wang Y., Dai W. Silk fibroin-based biomaterials for musculoskeletal tissue engineering. Materials Science and Engineering C. 2018; 89: 456–69.

Ma H.-L. et al. Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads. 2002.

Malinin T., Ouellette E. A. Articular cartilage nutrition is mediated by subchondral bone: a long-term autograft study in baboons. Osteoarthritis and Cartilage. 2000; 6(8): 483–91.

Matthews J.R. et al. Differences in Clinical and Functional Outcomes Between Osteochondral Allograft Transplantation and Autologous Chondrocyte Implantation for the Treatment of Focal Articular Cartilage Defects. Orthopaedic Journal of Sports Medicine. 2022; 2(10).

Mendez-Daza C.H., Arce-Eslava P.A. Reconstruction of a Distal Humeral Fracture with Articular Bone Loss Using Osteochondral Allograft: A Case Report. JBJS Case Connector. 2023; 2(13).

Mohammadinejad R. et al. Recent advances in natural gum-based biomaterials for tissue engineering and regenerative medicine: A review. Polymers. 2020; 12(1).

Moradkhannejhad L. et al. The effect of molecular weight and content of PEG on in vitro drug release of electrospun curcumin loaded PLA/PEG nanofibers. Journal of Drug Delivery Science and Technology. 2020; 56: 101554.

Moran J.M., Pazzano D., Bonassar L. J. Characterization of Polylactic Acid-Polyglycolic Acid Composites for Cartilage Tissue Engineering. 2003.

Moura C.S. et al. Chondrogenic differentiation of mesenchymal stem/stromal cells on 3D porous poly (ε-caprolactone) scaffolds: Effects of material alkaline treatment and chondroitin sulfate supplementation. Journal of Bioscience and Bioengineering. 2020; 6(129): 756–64.

Mullan C.J., Thompson L.J., Cosgrove A.P. The Declining Incidence of Legg-Calve-Perthes’ Disease in Northern Ireland: An Epidemiological Study. Journal of Pediatric Orthopaedics. 2017; 3(37): e178–82.

Murugan S., Parcha S.R. Fabrication techniques involved in developing the composite scaffolds PCL/HA nanoparticles for bone tissue engineering applications. Journal of Materials Science: Materials in Medicine. 2021; 8(32).

Naranda J. Recent advancements in 3d printing of polysaccharide hydrogels in cartilage tissue engineering. Materials. 2021; 14(14).

Nii T. Strategies using gelatin microparticles for regenerative therapy and drug screening applications. Molecules. 2021; 26(22).

Outerbridge R.E. The etiology of chondromalacia patellae. The journal of bone and joint surgery. 1961; 4(43): 752–8.

Park S. Bin et al. Poly(glutamic acid): Production, composites, and medical applications of the next-generation biopolymer. Progress in Polymer Science. 2021; 113: 101341.

Pavone V. et al. Aetiology of Legg-Calvé-Perthes disease: A systematic review. World Journal of Orthopedics. 2019; 10(3): 145–65.

Pei M. et al. Failure of xenoimplantation using porcine synovium-derived stem cell-based cartilage tissue constructs for the repair of rabbit osteochondral defects. Journal of Orthopaedic Research. 2010; 8(28): 1064–70.

Perotto G. et al. The optical properties of regenerated silk fibroin films obtained from different sources. Applied Physics Letters. 2017; 10(111).

Phatchayawat P.P. et al. 3D bacterial cellulose-chitosan-alginate-gelatin hydrogel scaffold for cartilage tissue engineering. Biochemical Engineering Journal. 2022; 184: 108476.

Rasouli M. et al. Bacterial Cellulose as Potential Dressing and Scaffold Material: Toward Improving the Antibacterial and Cell Adhesion Properties. Journal of Polymers and the Environment. 2023.

Reed S., Wu B.M. Biological and mechanical characterization of chitosan-alginate scaffolds for growth factor delivery and chondrogenesis. Journal of Biomedical Materials Research — Part B Applied Biomaterials. 2017; 2(105): 272–82.

Ren X. et al. Nanoparticulate mineralized collagen scaffolds induce in vivo bone regeneration independent of progenitor cell loading or exogenous growth factor stimulation. Biomaterials. 2016; 89: 67–78.

Rico-Llanos G. A. et al. Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering. Polymers. 2021; 4(13): 599.

Rol F. et al. Recent advances in surface-modified cellulose nanofibrils. Progress in Polymer Science. 2019; 88: 241–64.

Semenov A.V. Surgical treatment of stable foci of the osteochondritis dissecans in children: a systematic review. Russian Journal of Pediatric Surgery. 2021; 3(25): 179–85.

Shahverdi M. et al. Melt electrowriting of PLA, PCL, and composite PLA/PCL scaffolds for tissue engineering application. Scientific Reports. 2022; 1(12).

Shetye S.S. Materials in Tendon and Ligament Repair. Comprehensive Biomaterials II. 2017: 314–40.

Sheu M.T. et al. Characterization of collagen gel solutions and collagen matrices for cell culture. Biomaterials. 2001; 13(22): 1713–9.

Shirehjini L.M. et al. Poly-caprolactone nanofibrous coated with sol-gel alginate/ mesenchymal stem cells for cartilage tissue engineering. Journal of Drug Delivery Science and Technology. 2022; 74.

Shoulders M.D., Raines R.T. Collagen Structure and Stability. 2009; 78: 929–58. https://doi.org/10.1146/annurev.biochem.77.032207.120833.

Siddiqui N. et al. PCL-Based Composite Scaffold Matrices for Tissue Engineering Applications. Molecular Biotechnology. 2018; 60(7): 506–32.

Silva A. O. et al. Chitosan as a matrix of nanocomposites: A review on nanostructures, processes, properties, and applications. Carbohydrate Polymers. 2021; 272.

Subhan F. et al. A review on recent advances and applications of fish collagen. 2020; 6 (61): 1027–37. https://doi.org/10.1080/10408398.2020.1751585.

Thiede R.M., Lu Y., Markel M.D. A review of the treatment methods for cartilage defects. Veterinary and Comparative Orthopaedics and Traumatology. 2012; 25(4): 263–72.

Venkatesan J.K. et al. Biomaterial — guided recombinant adeno-associated virus delivery from poly (Sodium Styrene Sulfonate) — Grafted Poly (ε-Caprolactone) films to target human bone marrow aspirates. Tissue Engineering — Part A. 2020; 7–8(26): 450–9.

Vijayan A., Sabareeswaran A., Kumar G.S.V. PEG grafted chitosan scaffold for dual growth factor delivery for enhanced wound healing. Scientific Reports. 2019; 1(9).

Wang L. et al. Biodegradable poly-epsilon-caprolactone (PCL) for tissue engineering applications: a review. Rev. Adv. Mater. Sci. 2013; 34: 123–40.

Wang M. et al. Designing functional hyaluronic acid-based

hydrogels for cartilage tissue engineering. Materials Today Bio. 2022; 17.

Wang Z. et al. Visible light photoinitiation of cell-adhesive gelatin methacryloyl hydrogels for stereolithography 3D bioprinting. ACS Applied Materials and Interfaces. 2018; 32(10): 26859–69.

Wu Z. et al. Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering. Biomaterials and Biosystems. 2021; 4: 100030.

Yan H., Yu C. Repair of Full-Thickness Cartilage Defects With Cells of Different Origin in a Rabbit Model. Arthroscopy — Journal of Arthroscopic and Related Surgery. 2007; 2(23): 178–87.

Yang C. et al. The Application of Recombinant Human Collagen in Tissue Engineering. BioDrugs. 2004; 18: 2. 2012; 2(18): 103–19.

Yang J. et al. In vitro and in vivo Study on an Injectable Glycol Chitosan/Dibenzaldehyde-Terminated Polyethylene Glycol Hydrogel in Repairing Articular Cartilage Defects. Frontiers in Bioengineering and Biotechnology. 2021; 9.

Yang Z.G. et al. Restoration of cartilage defects using a superparamagnetic iron oxide-labeled adipose-derived mesenchymal stem cell and TGF-β3-loaded bilayer PLGA construct. Regenerative Medicine. 2020; 6(15): 1735–47.

Ying G. et al. Three-dimensional bioprinting of gelatin methacryloyl (GelMA). Bio-Design and Manufacturing. 2018; 1(4): 215–24.

Yuan H. et al. A novel bovine serum albumin and sodium alginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defects repair. Colloids and Surfaces B: Biointerfaces. 2020; 192.

Zha K. et al. Recent developed strategies for enhancing chondrogenic differentiation of MSC: Impact on MSC-based therapy for cartilage regeneration. Stem Cells International. 2021; 2021.

Zhang W. et al. A 3D porous microsphere with multistage structure and component based on bacterial cellulose and collagen for bone tissue engineering. Carbohydrate Polymers. 2020; 236: 116043.

Zhao J. et al. Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: A systematic review and meta-analysis. BMC Musculoskeletal Disorders. 2020; 1(21).

Zheng Y. et al. Bioinspired Hyaluronic Acid/Phosphorylcholine Polymer with Enhanced Lubrication and Anti-Inflammation. Biomacromolecules. 2019; 11(20): 4135–42.