UROMODULIN AND ITS ROLE IN THE FORMATION OF RENAL COMPONENTS IN CHILDREN AND ADOLESCENTS
Abstract
Urea stone disease (USD) in recent years has become much more common than 2-3 decades ago not only in the adult population, but also in children. The frequency of nephrolithiasis in the child population doubles every 10 years. One of the reasons may be a mutation of the gene encoding uromodulin, or the Tamma-Horsfall protein (THP) produced by the proximal section of the nephron tubule. The review presents data on the role of THP in regulating crystal formation, its function to protect the urinary tract from infection, and the significance of THP as one of the earliest markers of kidney injury