UROMODULIN AND ITS ROLE IN THE FORMATION OF RENAL COMPONENTS IN CHILDREN AND ADOLESCENTS

  • Natalia N Smirnova First Saint-Petersburg State Medical University named after academician I.P. Pavlov; Research Laboratory for the Diagnosis and Treatment of Childhood Pathology, Institute of Perinatology and Pediatrics of Almazov National Medical Research Centre 197022, Saint-Petersburg; 197341, Saint-Petersburg
  • Natalia B Kuprienko First Saint-Petersburg State Medical University named after academician I.P. Pavlov; Department of Childhood Diseases, Faculty of General Medicine, Institute of Medical Education, Almazov National Medical Research Centre 197022, Saint-Petersburg; 197341, Saint-Petersburg
Keywords: urea stone disease, children, uromodulin, gene UMOD mutation

Abstract

Urea stone disease (USD) in recent years has become much more common than 2-3 decades ago not only in the adult population, but also in children. The frequency of nephrolithiasis in the child population doubles every 10 years. One of the reasons may be a mutation of the gene encoding uromodulin, or the Tamma-Horsfall protein (THP) produced by the proximal section of the nephron tubule. The review presents data on the role of THP in regulating crystal formation, its function to protect the urinary tract from infection, and the significance of THP as one of the earliest markers of kidney injury

Author Biographies

Natalia N Smirnova, First Saint-Petersburg State Medical University named after academician I.P. Pavlov; Research Laboratory for the Diagnosis and Treatment of Childhood Pathology, Institute of Perinatology and Pediatrics of Almazov National Medical Research Centre 197022, Saint-Petersburg; 197341, Saint-Petersburg
ul. Leo Tolstoy, 6-8; Accuratova str., 2; MD, PhD, DSci (Medicine), Professor. Head of Department of Pediatrics. Academician I.P. Pavlov First Saint-Petersburg State Medical University; Researcher, Research Laboratory for the Diagnosis and Treatment of Childhood Pathology, Institute of Perinatology and Pediatrics of Almazov National Medical Research Centre
Natalia B Kuprienko, First Saint-Petersburg State Medical University named after academician I.P. Pavlov; Department of Childhood Diseases, Faculty of General Medicine, Institute of Medical Education, Almazov National Medical Research Centre 197022, Saint-Petersburg; 197341, Saint-Petersburg
ul. Leo Tolstoy, 6-8; Accuratova str., 2
Published
2022-03-09
How to Cite
Smirnova, N. N., & Kuprienko, N. B. (2022). UROMODULIN AND ITS ROLE IN THE FORMATION OF RENAL COMPONENTS IN CHILDREN AND ADOLESCENTS. Children’s Medicine of the North-West, 10(1), 44-48. Retrieved from https://ojs3.gpmu.org/index.php/childmed/article/view/3967
Section
Статьи