THE STATE OF THE INTESTINAL MICROBIOTA IN OBESE CHILDREN

Abstract

The aim. To assess the prevalence of the syndrome small intestinal bacterial overgrowth syndrome and the level of systemic endoxinemia, depending on the degree of constitutionally exogenous obesity in children. Materials and methods. 98 school age children with obesity were examined on the basis of the Donetsk City Children’s Clinical Hospital No. 1. The prevalence of the small intestinal bacterial overgrowth syndrome and the level of systemic endoxinemia was determined in all patients. Results of the study. Small intestinal bacterial overgrowth syndrome was detected in 72.4 ± 4.5 % of children with obesity, which was statistically significant (p < 0.001) more often than in the control group - 13.3 ± 6.2 %. Among patients with obesity I grade, small intestinal bacterial overgrowth syndrome was detected in 60.0 ± 7.7 %, among patients with obesity II grade - in 77.5 ± 7.6 %, and among patients with obesity III grade - in 91.7 ± 5.6 %. In the majority of obese patients, an increased concentration of lipopolysaccharide in the blood serum was detected - 67 (68.4 ± 4.7) %, which was statistically significant (p < 0.001) more relative to the control group and indicated the development of endotoxin aggression in these patients. Conclusions. Patients with constitutionally exogenous obesity are characterized by the presence of microbiotic intestinal imbalance, which is characterized by the formation of the small intestinal bacterial overgrowth syndrome and the development of endotoxin aggression.