CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF NON-HELICOBACTER CHRONIC GASTRITIS WITH EPSTEIN-BARR VIRUS PERSISTENCE IN CHILDREN

Abstract

Introduction. Chronic Hp unassociated gastritis in children is a little studied issue of gastroenterology. The aim of the study was to establish the features of clinical manifestations and pathomorphology of the gastric mucosa in children with chronic Hp unassociated gastritis with the persistence of Epstein-Barr virus. Material and methods. A total of 235 children aged 7-15 years were examined, among which 35 patients with Hp unassociated chronic gastritis were identified. The data of clinical and anamnestic, laboratory parasitological examination, esophagogastroduodenoscopy, gastrobiopsy were analyzed; the titer of antibodies to the parietal cells of the gastric mucosa was determined. The presence of Hp was detected by histological method with the staining of bacteria according to Romanovsky-Giemse or when the DNA of the infection was detected by polymerase chain reaction. The persistence of the Epstein-Barr virus was recorded by the same method. Results. The frequency of Hp unassociated chronic gastritis with persistence in the gastric mucosa of the Epstein-Barr virus was 6.4 %. Significant differences in clinical manifestations of the disease, depending on the presence or absence of the latter, were not revealed. Hp unassociated gastritis is characterized by a high frequency of giardiasis and combined worm parasitic invasion. According to morphological examination data, these patients have a predominant localization of superficial inflammation in the antral region with insignificant severity and activity. Morphological signs of atrophy occur in less than 10 % of cases. Conclusion. The persistence of the Epstein-Barr virus does not affect the characteristics of the inflammatory process in the gastric mucosa in Hp unassociated chronic gastritis in children.