PHENOTYPE OF BRONCHIAL ASTHMA IN CHILDREN WITH OBESITY

Abstract

Bronchial asthma (BA) in children is a common heterogeneous disease with chronic airway inflammation, the presence of respiratory symptoms such as whistling wheezing, shortness of breath, chest congestion and cough, which vary in time and intensity, and manifest together with variable airway obstruction. Among the factors contributing to BA weighting, one of the first places is obesity, which represents a heterogeneous group of inherited and acquired diseases associated with excessive accumulation of adipose tissue in the body. Children with BAD against a background of obesity are characterized by an uncontrollable or difficult to control course of the disease and a correspondingly low quality of life. The comorbidity of BA and obesity is due to a number of common exogenous and endogenous pathogenetic factors. The obese -asthmatic phenotype in children can be combined with atopy, insulin resistance, dyslipidemia, have an early or late onset in ontogenesis. Treatment of patients with BA with obesity is carried out in accordance with clinical recommendations for BA, there is no specific therapy of this phenotype. Identification of BA with obesity in children is crucial for treatment, since a timely multidisciplinary approach is needed to increase its effectiveness, as demonstrated by the above clinical case.