A CLINICAL CASE OF COVID-19 PNEUMONIA IN A PATIENT WITH INITIAL STATE OF ACUTE LYMPHOBLASTIC LEUKEMIA

Abstract

According to numerous studies, the incidence of children with new COVID-19 coronavirus infection (CoronaVirus Disease 2019) is significantly lower compared to adults and occurs mainly in mild and asymptomatic form; less than 1% of sick children have a severe disease course. In adults and children, the mechanisms of infection with the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome CoronaVirus 2) through receptors of the angiotensin -converting enzyme-2 (APF-2) are quite well studied, while knowledge of the pathogenesis of responses of the innate and adaptive immuneclearly not enough to understand the peculiarities of the course of this infection in each individual patient. A clinical case of bilateral SARS-CoV-2 pneumonia in a patient aged 14 years with acute lymphoblastic leukemia is presented (L2 BII immunological variant, I active phase, the onset of the disease prior specific treatment). On the example of a clinical case and based on literary sources, the hypothesis is confirmed that in many patients with deep disorders of immune mechanisms, COVID-19 disease can proceed relatively favorably and with less risk of developing delayed pathological immune -inflammatory complications in the form of multisystem inflammatory syndrome (MSVS).