MODERN CONCEPTS ON THE BIOLOGICAL ROLE AND CLINICAL SIGNIFICANCE OF CLAUDINS
Abstract
At present, suffi cient data and information have been accumulated on changes in claudins levels in various gastroenterological diseases. However, the issue of claudins content in intestinal pathologies remains poorly studied. Currently, post-giardiasis infl ammatory bowel disease (IBS) is being actively studied. According to Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor) in the Russian Federation, giardiasis ranks second after enterobiosis. Every year, up to 70–75% of children under the age of 17 fall ill with it. In addition, there is evidence that 5 to 10% of children diagnosed with IBS were previously infected Lamblia intestinalis. Giardiasis attacks the intestinal barrier and promotes the degradation of tight junction proteins such as Zo-1, claudin-1 and claudin-4. Claudins levels were decreased due to damage to the intestinal barrier. The role of excess claudins in IBD remains controversial. The studies examine the positive and negative eff ects of claudine-isoform levels on the human body depending on conditions. In addition to diseases, the level of claudins also depends on the content of cytokines.
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