MARKERS OF ACUTE KIDNEY INJURY IN CRITICALLY ILL PRETERM NEONATES

  • A.A. Volkova Privolzhsky Research Medical University. 10/1 Minin and Pozharsky pl., Nizhny Novgorod 603005 Russian Federation https://orcid.org/0000-0003-0560-616X
  • E.M. Kozlova Privolzhsky Research Medical University. 10/1 Minin and Pozharsky pl., Nizhny Novgorod 603005 Russian Federation
  • E.G. Novopoltseva Privolzhsky Research Medical University. 10/1 Minin and Pozharsky pl., Nizhny Novgorod 603005 Russian Federation
  • G.L. Shunkina City Clinical Hospital No. 40 of Avtozavodsky District of Nizhny Novgorod, Regional perinatal center. 71 Geroya Yuri Smirnova str., Nizhny Novgorod 603083 Russian Federation
  • A.N. Kolchina Privolzhsky Research Medical University. 10/1 Minin and Pozharsky pl., Nizhny Novgorod 603005 Russian Federation
  • N.A. Rakhmanova Nizhny Novgorod Regional Children’s Clinical Hospital. 211Vaneeva str., Nizhny Novgorod 603136 Russian Federation
  • A.O. Shmeleva Privolzhsky Research Medical University. 10/1 Minin and Pozharsky pl., Nizhny Novgorod 603005 Russian Federation
DOI: https://doi.org/10.56871/CmN-W.2024.10.85.012
Keywords: acute kidney injury, creatinine, cystatin C, urine b2-microglobulin, preterm neonate, very low birth weight, extremely low birth weight

Abstract

Early diagnosis of acute kidney injury (AKI) in very low birth weight (VLBW) and extremely low birth weight (ELBW) preterm infants is a serious problem due to the lack of specifi c clinical manifestations, metabolic features, immaturity of the renal tubular and tubule apparatus, and the intensive therapy provided. The aim of the study is to compare the diagnostic value of classical markers of AKI(diuresis and serum creatinine) and other biochemical parameters (serum cystatin C and urine b2-microglobulin) in children of this group in critical condition. A total of 100 neonates with VLBW and ELBW were included in the study, 28 of whom developed AKI during the fi rst week of life (main group). Oliguria did not develop in any child, and a diagnostically signifi cant increase in serum creatinine was noted on the third day of life. An increase in serum creatinine and urine b2- microglobulin levels in children of the main group compared to the comparison group was detected already on the fi rst day, which allows us to consider them more sensitive markers. However, the reference values of the indicators in children with VLBW and ELBW need to be clarified.

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Published
2024-10-09
How to Cite
Volkova, A., Kozlova, E., Novopoltseva, E., Shunkina, G., Kolchina, A., Rakhmanova, N., & Shmeleva, A. (2024). MARKERS OF ACUTE KIDNEY INJURY IN CRITICALLY ILL PRETERM NEONATES. Children’s Medicine of the North-West, 12(2), 135-144. https://doi.org/10.56871/CmN-W.2024.10.85.012
Issue
Vol 12 No 2 (2024)
Section
Статьи