A CLINICAL CASE OF A CHILD WITH TYPE I DIABETES MELLITUS WITH THE SUBSEQUENT DEVELOPMENT OF ENCEPHALOPATHY

  • N.V. Evdokimova Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100 https://orcid.org/0000-0001-9812-6899
  • A.A. Timofeev Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
  • A.N. Zavyalova Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
  • M.N. Yakovleva Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
  • K.V. Skobeleva Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
Keywords: type 1 diabetes mellitus (DM1), diabetic encephalopathy (DE), diabetic coma, metabolic acidosis treatment of DM1, children

Abstract

The aim of the work was to review a clinical case of a child with type 1 diabetes mellitus (DM1) with severe cognitive impairment due to the development of diabetic encephalopathy. The analysis of the preceding factors of the manifestation of DM1 in a child is carried out, as a result of which, against the background of prolonged hyperglycemia and insulin defi ciency, there was an increase in metabolic acidosis with a subsequent complication in the form of diabetic encephalopathy (DE). Subsequent metabolic and hypoxic changes in the child’s body led to a decrease in cognitive functions.DE is a characteristic complication of DM1 in children, since its development is mainly due to ineff ective metabolic control, as well as incorrectly selected therapy. An assessment of anthropometric data, as well as laboratory parameters, was carried out before and after adjusting the treatment of DM1.

References

Дедова И.И., Шестакова М.В., Майорова. А.Ю. и др. Острые осложнения сахарного диабета. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. М.; 2021. DOI: 10.14341/DM12802.

Леонова Т.С., Вихинина М.В., Гришина Т.В., Леонова Л.Е. Фролов А.А., Романовская Е.В. Влияние конечных продуктов глубокого гликирования на клеточные процессы. Международный научно-исследовательский журнал. 2018;12-1(78):194–185. DOI: 10.23670/IRJ.2018.78.12.034.

Петеркова В.А., Шестакова М.В., Безлепкина О.Б. и др. Общественная организация Российская ассоциация эндокринологов. Клинические рекомендации. М.; 2020. DOI: 10.14341/DM20201S.

Российская ассоциация эндокринологов. Клинические рекомендации. Сахарный диабет 1 типа у детей. М.; 2022.

Сопрун Л.А., Утехин В.И., Гвоздецкий А.Н., Акулин И.М., Чурилов Л.П. Антропогенные факторы окружающей среды как триггеры сахарного диабета 1-го типа у детей. Педиатр. 2020; 11(2): 57–65. DOI: 10.17816/PED11257-65.

Худорожкова О.М., Смирнова Е.Н. Особенности манифестации сахарного диабета 1-го типа у детей и подростков, проживающих в Пермском крае. Педиатр. 2019; 10(5):56–51. DOI: 10.17816/PED10551-56.

Eslami Gharaati M., Nahavandi А., Baluchnejad Mojarad T., Roghani M. Diabetic Encephalopathy Affecting Mitochondria and Axonal Transport Proteins. Basic Clin Neurosci. 2020;11(6):793–781. DOI: 10.32598/bcn.11.6.1657.1.

European Association for the Study of the Li­ver. EASL Clinical Practice Guidelines on the ma­nagement of hepatic encephalopathy. Journal of Hepatology. 2022;77(3):824–807. DOI: 10.1016/j.jhep.2022.06.001.

Jiang L., Yuan N., Zhao N., Tian P., Zhang D. Advanced glycation end products induce Aβ1-42 deposition and cognitive decline through H19/miR-15b/BACE1 axis in diabetic encephalopathy. Brain Research Bulletin. 2022;1(188):196–187.DOI: 10.1016/j.brainresbull.2022.08.007

John E. H., Arthur C.G. Guyton and Hall Textbook of Medical Physiology. Jackson, Mississippi: Elsevier Inc; 2018.

John W., Wiebke A., Robert S. eds. Oxford Textbook of Endocrinology and Diabetes 3 rd ed. Oxford England: Oxford University Press; 2021.

Joseph I.W., Nicole G., Michael A. eds. ISPAD Cli­nical Practice Consensus Guidelines 2018: Diabetic ketoacidosis and the hyperglycemic hyperosmolar state. Pediatric Diabetes. 2018;19(27):177–155. DOI: 10.1111/pedi.12701.

Marois C., Quirins M., Hermann B., Mouri S., Bouzbib C., Rudler M. Metabolic encephalopathies. La Revue de Médecine Interne. 2019;40(2):97–87. DOI: 10.1016/j.revmed.2018.11.006.

Ralph Z., Andreas N. Diabetes in Childhood and Adolescence. Dtsch Arztebl Int. 2018;115:13–1. DOI: 10.3238/arztebl.2018.0146.

Tomkins M., McCormack R., O’Connell K. Metabolic encephalopathy secondary to diabetic ketoacidosis: a case report.BMC Endocr Disord. 2019;19(1):71. DOI: 10.1186/s12902-019-0398-8.

Zhang R., Jiang L., Li G., Wu J. Advanced Glycosy­lation End Products Induced Synaptic Deficits and Cognitive Decline Through ROS-JNK-p53/miR-34c/SYT1 Axis in Diabetic Encephalopathy. J Alzheimers Dis. 2022;87(2):861–843. DOI: 10.3233/JAD-215589.

Никитина И.Л., Скородок Ю.Л., Дитковская Л.В., Новикова В.П., Гринева Е.Н. Сахарный диабет у детей и подростков. Учебное пособие. М.: 2016.

Published
2024-10-11
How to Cite
Evdokimova, N., Timofeev, A., Zavyalova, A., Yakovleva, M., & Skobeleva, K. (2024). A CLINICAL CASE OF A CHILD WITH TYPE I DIABETES MELLITUS WITH THE SUBSEQUENT DEVELOPMENT OF ENCEPHALOPATHY. Children’s Medicine of the North-West, 12(2), 211-219. https://doi.org/10.56871/CmN-W.2024.43.69.020
Section
Статьи