UPPER GASTROINTESTINAL MORPHOLOGICAL CHANGES IN CROHN'S DISEASE (LITERATURE REVIEW)
Abstract
In 1932, Burrill Bernard Kron, Leon Ginsberg and Gordon Oppenheimer published an article entitled “Regional Ileitis:Pathological and Clinical Essence”, in which they fi rst described terminal ileitis, later named B. Kron. Crohn’s disease (CD) is a recurrent systemic infl ammatory disease aff ecting the gastrointestinal tract with extraintestinal manifestations and systemic immunological disorders. It can be localized in all parts of the gastrointestinal tract and is characterized by a variety of intestinal and extraintestinal manifestations, which depend on the depth, length of the aff ected organ and the characteristics of immune (systemic) complications. Upper gastrointestinal tract lesions in this disease are an understudied area. Routine screening showed a higher prevalence of the described pathology among children compared to adults. Upper gastrointestinal involvement in Crohn’s disease is an understudied area. Routine screening showed a higher prevalence of this pathology among children compared to adults. In most patients, damage to the upper gastrointestinal tract remains asymptomatic, but pathological changes in the mucous membrane, diagnosed by morphological examination, are possible. In routine practice, endoscopic examination is recommended for patients with pre-existing lesion symptoms. This literature review considers morphological changes in the upper gastrointestinal tract in Crohn’s disease, which are a consequence of both the underlying disease and the side eff ects of drugs used in the treatment of this pathology.
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