INFLUENCE OF OVERWEIGHT AND OBESITY ON REVERSIBILITY OF BRONCHIAL OBSTRUCTION IN CHILDREN WITH BRONCHIAL ASTHMA
Abstract
Introduction. Most modern publications report the formation of an obstructive pattern of external respiration in children with a combination of bronchial asthma (BA) and obesity, including due to the formation of dysanapsis in them. However, data on the effect of overweight and obesity on the reversibility of bronchial obstruction in patients with BA and obesity are rare and contradictory. The aim of the study was to study the effect of overweight and obesity on the reversibility of bronchial obstruction in children and adolescents with asthma. Materials and methods. A single-center observational cross-sectional pilot study was conducted. 161"patients with asthma aged from 8 to 17 years were examined. Anthropometric and spirometric parameters were measured, z body mass index (BMI), WC (waist circumference)/height, bronchodilation coefficient (BDC) were calculated. The study participants were divided into two groups: group 1 — with normal body weight (BW), group 2"— with overweight, obesity. Results. BDC was statistically significantly lower in the group with overweight, obesity, amounting to 5.57 [1.07; 9.16]% versus 10.20 [3.67; 17.94]%, p"<0.001. BDC was statistically significantly lower in the group with abdominal type of obesity, amounting to 5.83 [1.07; 9.16]% versus 7.67 [3.67; 13.76]%, p=0.034. Negative correlations were found between BDC and z BMI, WC/height, R=–0.29, p=0.0002, R=–0.31, p=0.004, respectively. Conclusions. In patients with BA and overweight, obesity, the reversibility of bronchial obstruction in tests with bronchodilators is lower than in patients with normal BW. This may reflect the formation of a fixed obstruction component in overweight and obese patients.
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