DRAFT CLINICAL RECOMMENDATIONS FOR NEONATOLOGISTS AND PEDIATRICIANS ON THE MANAGEMENT OF NEWBORN CHILDREN SUFFERING FROM REGURGITATION / RUMINATION (FOR DISCUSSION BY SPECIALISTS)
Abstract
The practical recommendations are intended to optimize the tactics of managing newborns with regurgitation and are offered for use by neonatologists, pediatricians, gastroenterologists working in the outpatient healthcare of the Russian Federation, as well as all specialists who are interested in neonatology and clinical gastroenterology. These practical recommendations are offered for public discussion and are posted in full on the website of the Russian Society of Neonatologists: https://neonatology.pro.
References
Бельмер С.В., Хавкин А.И., Печкуров Д.В. Функциональные нарушения органов пищеварения у детей. Принципы диагностики и лечения (в свете Римских критериев IV). М.: ГЭОТАР-Медиа; 2017.
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition: DSM-5-TR. Washington, DC: American Psychiatric Association Publishing; 2022.
Drossman D.A. H.W.L. Rome IV — Functional GI disorders: Disorders of gut-brain interaction. Gastroenterology. 2016;150(6):1257–61. DOI: 10.1053/j.gastro.2016.03.035.
Rosen R., Vandenplas Y., Singendonk M. et al. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. Author manuscript; available in PMC 2019 Mar 1. Published in final edited form as: J Pediatr Gastroenterol Nutr. 2018;66(3):516–554. DOI: 10.1097/MPG.0000000000001889.
Kusnik A., Vaqar S. Rumination Disorder In: Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 2024 Jan.2023 May 8.
Vandenplas Y., Alturaiki M.A., Al-Qabandi W., AlRefaee F. et al. Middle East Consensus Statement on the Diagnosis and Management of Functional Gastrointestinal Disorders in <12 Months Old Infants. Pediatr Gastroenterol Hepatol Nutr. 2016;19(3):153–161. DOI: 10.5223/pghn.2016.19.3.153.
Бельмер С.В., Волынец Г.В., Горелов А.В., Гурова М.М., Звягин А.А., Корниенко Е.А., Новикова В.П., Печкуров Д.В., Приворотский В.Ф., Тяжева А.А., Файзуллина Р.А., Хавкин А.И., Эрдес С.И. Функциональные расстройства органов пищеварения у детей. Рекомендации Общества детских гастроэнтерологов, гепатологов и нутрициологов. Часть 1. Рос. Вестн. перинатол. и педиатр. 2020;65(4):150–161. DOI: 10.21508/1027-4065-2020-65-4-150-161.
Chew K.S., Em J.M., Koay Z.L., Jalaludin M.Y., Ng R.T., Lum L.C.S., Lee W.S. Low prevalence of infantile functional gastrointestinal disorders (FGIDs) in a multi-ethnic Asian population. Pediatr Neonatol. 2021;62(1):49–54. DOI: 10.1016/j.pedneo.2020.08.009.
Robin S.G. Keller C. Zwiener R. Hyman P.E. et al. Prevalence of pediatric functional gastrointestinal disorders utilizing the Rome IV criteria. J Pediatr. 2018;195:134–139. DOI: 10.1016/j.jpeds.2017.12.012.
Van Tilburg M.A. Hyman P.E. Walker L. Rouster A. et al. Prevalence of functional gastrointestinal disorders in infants and toddlers. J Pediatr. 2015;166:684–689. DOI: 10.1016/j.jpeds.2014.11.039.
Campanozzi A., Boccia G., Pensabene L., Panetta F., Marseglia A., Strisciuglio P. et al. Prevalence and natural history of gastroesophageal reflux: pediatric prospective survey. Pediatrics. 2009;123(3):779–83. DOI: 10.1542/peds.2007-3569123: 779-783.
Шиляев Р.Р., Петрова О.А., Копилова Е.Б. Синдром срыгиваний и рвоты у детей раннего возраста. Современные подходы к диагностике и лечению. Учебно-методическое пособие. Иваново: ИГМА; 2001.
Rajindrajith S., Devanarayana N.M., Perera BJC. Rumination syndrome in children and adolescents: A school survey assessing prevalence and symptomatology. BMC Gastroenterol. 2012;16(12):163. DOI: 10.1186/1471-230X-12-163.
Palsson O., Whitehead W., van Tilburg M. et al. Rome IV diagnostic questionnaires and tables for investigators and clinicians. Gastroenterology. 2016;150:1481–91. DOI: 10.1053/j.gastro.2016.02.014.
Murray H.B., Thomas J.J., Hinz A. et al. Prevalence in primary school youth of pica and rumination behavior: The understudied feeding disorders. Int J Eat Disord. 2018;51(8):994–8. DOI: 10.1002/eat.22898.
Koloski N.A., Talley N.J., Boyce P.M. Epidemiology and health care seeking in the functional GI disorders: A population-based study. Am J Gastroenterol. 2002;97(9):2290–9. DOI: 10.1111/j.1572-0241.2002.05783.x.
Hartmann A.S., Poulain T., Vogel M. et al. Prevalence of pica and rumination behaviors in German children aged 7–14 and their associations with feeding, eating, and general psychopathology: A population-based study. Eur Child Adolesc Psychiatry 2018:27(11):1499–508. DOI: 10.1007/s00787-018-1153-9.
Murray H.B., Juarascio A.S., Di Lorenzo C., Drossman D.A., Thomas J.J. Diagnosis and Treatment of Rumination Syndrome: A Critical Review. Am J Gastroenterol. 2019;114(4):562–578. DOI: 10.14309/ajg.0000000000000060.
ФГАУ «НМИЦ здоровья детей» МЗ РФ. Программа оптимизации вскармливания детей первого года жизни в Российской Федерации: методические рекомендации. 2019.
Farahmand F., Najafi M., Ataee P., Modarresi V., Shahraki T., Rezaei N.Cow’s milk allergy among children with gastroesophageal reflux disease. Gut Liver. 2011;5(3):298–301. DOI: 10.5009/gnl.2011.5.3.298.
Vandenplas Y., Gutierrez-Castrellon P., Velasco-Benitez C., Palacios J., Jaen D. et al. Practical algorithms for managing common gastrointestinal symptoms in infants. Nutrition. 2013;29:184–194. DOI: 10.1016/j.nut.2012.08.008.
Bi D., Jiang H., Yang K., Guan T., Hou L., Shu G. Neonatal risk factors for functional gastrointestinal disorders in preterm infants in the first year of life. Turk J Pediatr. 2023;65(6):919–930. DOI: 10.24953/turkjped.2022.1089.
Gondim MMBB., Goulart A.L., Morais M.B. Prematurity and functional gastrointestinal disorders in infancy: a cross-sectional study. Sao Paulo Med J. 2022;140(4):540–546. DOI: 10.1590/1516-3180.2021.0622.R1.29102021.
Aydemir Y., Aydemir O., Dinleyici M., Saglik A.C., Cam D. et al. Screening for functional gastrointestinal disorders in preterm infants up to 12 months of corrected age: a prospective cohort study. Eur J Pediatr. Springer Berlin Heidelberg, 2024;183(5):2091–2099. DOI: 10.1007/s00431-024-05451-4.
Halland M., Parthasarathy G., Bharucha A.E. et al. Diaphragmatic breathing for rumination syndrome: efficacy and mechanisms of action. Neurogastroenterol Motil. 2016;28:384–91. DOI: 10.1111/nmo.12737.
Van Den Driessche M., Peeters K., Marien P., Ghoos Y., Devlieger H., Veereman-Wauters G. Gastric emptying in formula-fed and breast-fed Infants measured with the 13C-octanoic acid breath test. J Pediatr Gastroenterol Nutr. 1999;29(1):46–51. DOI: 10.1097/00005176-199907000-00013.
Cavataio F., Iacono G., Montalto G., Soresi M., Tumminello M., Carroccio A. Clinical and pH-metric characteristics of gastro-oesophageal reflux secondary to cows’ milk protein allergy. Arch Dis Child. 1996;75:51–56. DOI: 10.1136/adc.75.1.51.
Milocco C., Torre G., Ventura A. Gastro-oesophageal reflux and cows’ milk protein allergy. Arch Dis Child. 1997;77:183–184. DOI: 10.1136/adc.77.2.183a.
Malcolm A., Thumshirn M.B., Camilleri M., Williams D.E. Rumination syndrome. Mayo Clin Proc. 1997;72(7):646–52. DOI: 10.1016/S0025-6196(11)63571-4.
Chahuan J., Rey P., Monrroy H. Rumination syndrome. A review article. Rev Gastroenterol Mex (Engl Ed). 2021;86(2):163–171. DOI: 10.1016/j.rgmx.2020.11.001.
Halland M., Parthasarathy G., Bharucha A.E. et al. Diaphragmatic breathing for rumination syndrome: efficacy and mechanisms of action. Neurogastroenterol Motil. 2016;28:384–91. DOI: 10.1111/nmo.12737.
Tack J., Blondeau K., Boecxstaens V. et al. Review article: the pathophysiology, differential diagnosis and management of rumination syndrome. Aliment Pharmacol Ther. 2011;33:782–8. DOI: 10.1111/j.1365-2036.2011.04584.x.
Barba E., Burri E., Accarino A. et al. Biofeedback guided control of abdominothoracic muscular activity reduces regurgitation episodes in patients with rumination. Clin Gastroenterol Hepatol. 2015;13:100–6. DOI: 10.1016/j.cgh.2014.04.018.
Alcala-Gonzalez L.G., Serra X., Barba E. Rumination syndrome: Critical review. Gastroenterol Hepatol. 2022;45(2):155–163. DOI: 10.1016/j.gastrohep.2021.03.013.
Vandenplas Y., Ashkenazi A., Belli D. et al. A proposition for the diagnosis and treatment of gastro-oesophageal reflux disease in children: a report from a working group on gastro-oesophageal reflux disease. Working group of the european society of Paediatric gastro-enterology and Nutrition (ESPGHAN). Eur J Pediatr. 1993;152(9):704–711. DOI: 10.1007/BF01953980.
Захарова И.Н., Сугян Н.Г., Пыков М.И. Синдром срыгивания у детей раннего возраста: диагностика и коррекция. Эффективная фармакотерапия. 2014;3:18–28.
O’Brien M.D., Bruce B.K., Camilleri M. The rumination syndrome: Clinical features rather than manometric diagnosis. Gastroenterology. 1995;108(4):1024–9. DOI: 10.1016/0016-5085(95)90199-x.
Stanghellini V., Chan F.K., Hasler W.L, et al. Gastroduodenal disorders. Gastroenterology. 2016;150(6):1380–92. DOI: 10.1053/j.gastro.2016.02.011.
Vijayvargiya P., Iturrino J., Camilleri M. et al. Novel association of rectal evacuation disorder and rumination syndrome: Diagnosis, comorbidities, and treatment. United European Gastroenterol J. 2014:2(1):38–46. DOI: 10.1177/2050640613518774.
Koppen I.J., Nurko S., Saps M., Di Lorenzo C., Benninga M.A. The pediatric Rome IV criteria: what’s new? Expert Rev Gastroenterol Hepatol. 2017;11(3):193–201. DOI: 10.1080/17474124.2017.1282820.
Wien M.A., Whitehead M.T., Bulas D., Ridore M., Melbourne L. et al. Patterns of brain injury in newborns treated with extracorporeal membrane oxygenation. AJNR Am J Neuroradiol. 2017;38(4):820–826. DOI: 10.3174/ajnr.A5092.
Hyams J., Ricci J. L.A. Clinical and laboratory correlates of esophagitis in young children. J Pediatr Gastroenterol Nutr. 1988;7(1):52–6. DOI: 10.1097/00005176-198801000-00011.
Gonzalez Ayerbe J.I., Hauser B., Salvatore S., Vandenplas Y. Diagnosis and management of gastroesophageal reflux disease in infants and children: From guidelines to clinical practice Pediatr Gastroenterol Hepatol Nutr. 2019;22(2):107–121. DOI: 10.5223/pghn.2019.22.2.107.
Duncan D.R., Amirault J., Mitchell P. et al. Oropharyngeal Dysphagia is Strongly Correlated With Apparent Life-Threatening Events. J Pediatr Gastroenterol Nutr. 2017;65(2):168–72. DOI: 10.1097/MPG.0000000000001439.
Weir K.A., McMahon S., Taylor S. et al. Oropharyngeal aspiration and silent aspiration in children. Chest. 2011;140(3):589–97. DOI: 10.1378/chest.10-1618.
Weir K., McMahon S., Barry L. et al. Clinical signs and symptoms of oropharyngeal aspiration and dysphagia in children. Eur Respir J. 2009;33(3):604–11. DOI: 10.1183/09031936.00090308.
Tucker E., Knowles K., Wright J. et al. Rumination variations: aetiology and classification of abnormal behavioural responses to digestive symptoms based on high-resolution manometry studies. Aliment Pharmacol Ther. 2013;37(2):263–74. DOI: 10.1111/apt.12148.
Kessing B.F., Bredenoord A.J., Smout A.J. Objective manometric criteria for the rumination syndrome. Am J Gastroenterol. 2014;109(1):52–9. DOI: 10.1038/ajg.2013.428.
Rosen R., Rodriguez L., Nurko S. Pediatric rumination subtypes: A study using high-resolution esophageal manometry with impedance. Neurogastroenterol Motil. 2017;29(5):10. DOI: 10.1111/nmo.12998.
Singendonk MMJ., Oors J.M., Bredenoord A.J. et al. Objectively diagnosing rumination syndrome in children using esophageal pH-impedance and manometry. Neurogastroenterol Motil. 2017;29(5):1–8. DOI: 10.1111/nmo.12996.
Grunder F.R., Aspirot A., Faure C. High-Resolution Esophageal Manometry Patterns in Children and Adolescents with Rumination Syndrome. J Pediatr Gastroenterol Nutr. 2017;65(6):627–632. DOI: 10.1097/MPG.0000000000001618.
Неонатология. Национальное руководство под ред. Н.Н. Володина, Д.Н. Дегтярева. М.: ГЭОТАР-Медиа. 2023;2.
Bellaiche M., Tounian P., Oozeer R., Rocher E., Vandenplas Y. Digestive Tolerance and Safety of an Anti-Regurgitation Formula Containing Locust Bean Gum, Prebiotics and Postbiotics: A Real-World Study. Pediatr Gastroenterol Hepatol Nutr. 2023;26(5):249–265. DOI: 10.5223/pghn.2023.26(5):249-65.
Salvatore S., Klymenko V., Karpushenko Y., Durczak-Hilleman M., Loboda A. et. al. Tolerance and Safety of an Anti-Regurgitation Formula Containing Locust Bean Gum, Pre-, and Postbiotics: A Multi-Country Multi-Center Prospective Randomized Controlled Study in Infants with Regurgitation. Nutrients. 2024;16(6):899. DOI: 10.3390/nu16060899.
Corvaglia L., Mariani E., Aceti A., Galletti S., Faldella G. Extensively hydrolyzed protein formula reduces acid gastro-esophageal reflux in symptomatic preterm infants Early Hum Dev. 2013;89(7):453–5. DOI: 10.1016/j.earlhumdev.2013.04.003.
Salvatore S., Abkari A., Cai W., Catto-Smith An., Cruchet S., Gottrand F., et. al. Review shows that parental reassurance and nutritional advice help to optimise the management of functional gastrointestinal disorders in infants Acta Paediatr. 2018;107(9):1512–1520. DOI: 10.1111/apa.14378.
Lightdale J.R., Gremse D.A. Section on Gastroenterology, Hepatology and Nutrition Gastroesophageal reflux: Management guidance for the pediatrician. Pediatrics. 2013;131:e1684–e1695. DOI: 10.1542/peds.2013-0421.
Puntis J.W. Gastro-oesophageal reflux in young babies: Who should be treated? Arch. Dis. Child. 2015;100(10):989–993. DOI: 10.1136/archdischild-2014-306232.
Tighe M.P., Andrews E., Liddicoat I., Afzal N.A., Hayen A., Beattie R.M. Pharmacological treatment of gastro-oesophageal reflux in children Cochrane Database Syst Rev. 2023;8(8):CD008550. DOI: 10.1002/14651858.CD008550.pub3.
Carabelli G., Binotto I., Armano C., Bertù L., Luini C., Nosetti L., Agosti M., Salvatore S. Study on Nocturnal Infant Crying Evaluation (NICE) and Reflux Disease (RED). Children (Basel). 2024;11(4):450. DOI: 10.3390/children11040450.
Fernández-González S.M., Moreno-Álvarez A., Solar-Boga A. Proton Pump Inhibitors in Pediatric Gastroesophageal Reflux Disease: A Systematic Review of Randomized Controlled Trials. Children (Basel). 2024;11(3):296. DOI: 10.3390/children11030296.
Health N.C.C. for W. and C. Gastro-oesophageal reflux disease: recognition, diagnosis and management in children and young people. NICE Guideline, National Institute for Health and Care Excellence. London; 2015.
Tighe M.P., Afzal N.A., Bevan A., Beattie R.M. et al. Current Pharmacological Management of Gastro-Esophageal Reflux in Children. Paediatr Drugs. 2009;11(3):185–202. DOI: 10.2165/00148581-200911030-00004.
Van Der Pol R.J., Smits M.J., van Wijk M.P., Omari T.I., Tabbers M.M., Benninga M.A., et al. Efficacy of proton-pump inhibitors in children with gastroesophageal reflux disease: A systematic review. Pediatrics. 2011;127(5):925–35. DOI: 10.1542/peds.2010-2719.
Baldassarre M.E., Di Mauro A., Pignatelli M.C., Fanelli M., Salvatore S., Di Nardo G. et al. Magnesium alginate in gastro-esophageal reflux: a randomized multicenter cross-over study in infants. Int J Environ Res Public Health. 2019;17(1):83. DOI: 10.3390/ijerph17010083.
Martin A.J., Pratt N., Kennedy J.D., Ryan P., Ruffin R.E., Miles H., Marley J. Natural history and familial relationships of infant spilling to 9 years of age. Pediatrics. 2002;109:1061–1067. DOI: 10.1542/peds.109.6.1061.
