FEATURES OF OXIDATIVE STRESS AND ANTIOXIDANT SYSTEM IN CHILDREN WITH CROHN’S DISEASE, TAKING INTO ACCOUNT THE FORM OF THE DISEASE
Abstract
Introduction. Inflammatory bowel diseases are chronic recurrent diseases of unknown etiology that often lead to disability. They include Crohn's disease and ulcerative colitis. In complicated forms of Crohn's disease, the prognosis is the most unfavorable in patients, especially in children, since they require surgical treatment, which at this stage should be prevented at the stage of diagnosis. The aim of the work is to prove the relationship between the development of the stricturing form of Crohn's disease and the imbalance of oxidative stress and the antioxidant system. Materials and methods. The sample consisted of 16 patients with inflammatory Crohn's disease and 10 patients — a group with a stricturing form. All patients underwent a study of oxidative stress biomarkers (plasma ischemia modifying albumin (IMA), plasma malondialdehyde (MDA) and the antioxidant system (plasma SH groups, catalase and reduced glutathione of erythrocytes). Conclusion. The obtained results showed a clear relationship between the activity of oxidative stress and antioxidant deficiency in the formation of the stricturing form of Crohn's disease, which can be used in prognostication at the onset of the disease.
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