EFFECT OF THYROID STATUS ON REMYELINATION PROCESSES
Abstract
The number of demyelinating diseases of central nervous system are prone to grow nowadays. The most socially significant and well studied one is multiple sclerosis. The search of susbstances that would stop demyelinisation or reinforce the process of remyelination is in great request. Thyreoid gland hormones play a sufficient role in nervous system functioning and developing. Some studies show, that triiodothyronine regulates myelin synthesis through thyroid sensitive nuclear receptors. In our study process of demyelination were modelled via cuprizone model, which appears to be an optimal method, since it allows to witness the process of demyelination without an autoimmune component. Results of the study show effectiveness of thyroid hormones for myelin and axon protection.
