3D modeling of the hemodynamic process of the portal vein system in normal and pathological conditions

Abstract

The development of a closed mathematical model of hemodynamic processes is normal in the case of portal hypertension syndrome in the portal vein system. Materials and methods. In the period from 2000 to 2020, a study was made of the structures of the portal vein, at different age periods. Sectional material was the structure of the portal portal vein of the liver taken from children, adolescents, and adults who died as a result of accidents and against the background of portal hypertension - 89 objects. The age group was: children 7-12 years old - 18 (20.2 %); 13-17 years old - 16 (18.0 %); 18-21 - 24 (27.0 %); 22-30 years - 31 (34.8 %) cases. 3D models were printed: 3D printer: Zortrax M200 (Poland) with a working chamber volume of 200 mm x 200 mm x 185 mm; FORMLABS FORM 2 (USA). In the process of creating an opaque 3D model and topical angioprosthetics on a Zortrax M200 3D printer, FLEX REC 2.85mm plastic in red, white and green was used. Results. Software creation of a three dimensional geometric model and refinement of its grid according to the resulting morphological parameters. Based on data from computed tomography (CT) and magnetic resonance imaging (MRI) with a spiral course. To obtain the initial parameters of blood flow velocity in the simulated area, an ultrasound scanner was used, equipped with a linear sensor with an operating frequency of at least 5 MHz. It establishes a change in blood flow velocity in various parts of the studied section of the vascular bed (directly in the lumen of the implant, at the border of the anastamoses) in the time period set by the program operator, and also determines the changes in the nature of the blood flow - from laminar to turbulent - and pressure indicators in the studied section. Conclusion. The development of a method for creating a three dimensional model of a section of the vascular bed will allow us to reliably describe the processes occurring in the investigated section of the vessel. Allows you to understand the dynamic changes in the hydrodynamic parameters of blood flow in normal and with vascular pathology.