STUDY OF THE NON-SPECIFIC INFLUENCE OF TYPICAL NEUROLEPTICS ON THE CONDITION OF THE THYROID GLAND

Abstract

Modern human conditions are associated with a constant influence of stressful effects. It is proved that it is an important factor in the emergence and progression of various diseases, including mental and psycho neurological pathologies. In this regard, the nonspecific effects of psychotropic drugs today are an important and urgent problem of pharmacology, since their frequency of use is increasing due to an increase in the incidence, and, as a result, the frequency of adverse and undesirable reactions to their intake. One of the most important groups of drugs used to treat and stop mental illnesses are antipsychotics, in particular first generation drugs - “typical antipsychotics”. They have a pronounced antipsychotic effect, but specific side effects that are equally pronounced are extrapyramidal disorders: antipsychotic parkinsonism, akathasia, as well as malignant antipsychotic syndrome, the severity of which once served as an indicator of the therapeutic effect, and which have been adequately studied. In addition to these specific side effects, antipsychotics may have a nonspecific effect on the body. In this work, an attempt was made to study the effect of typical antipsychotics on the hypothalamic pituitary thyroid system, and primarily on the thyroid gland. In an experiment on an acute stress model, neuroleptic therapy was carried out in high doses for a duration of 14 days. Haloperidol was used as a typical antipsychotic, and the model of “drowning stress” was chosen as a model of acute stress. After the end of therapy, a blood was taken to study the level of hormones. The preliminary results obtained by enzyme linked immunosorbent assay indicate that typical antipsychotics inhibit the hypothalamic pituitary thyroid system, which is reflected in a decrease in the synthesis and secretion of its hormones. These data confirm the thesis of the authors, but need further study.