Danio rerio (zebrafish) - an universal model object in preclinical studies

Abstract

Danio rerio (Zebrafish) as a model object in preclinical studies has been widely used in recent years. This is facilitated by their morphological, physiological, biochemical, genetic and embryological peculiarities, as well as economic benefits and low time costs for their breeding. The aim - summarize the available data on the use of Danio rerio (Zebrafish) in preclinical studies. Methods In this paper, a retrospective analysis of domestic and foreign works on the use of Danio rerio in toxicological, pharmacological, embryological, and other areas of research has been carried out. Methods in this paper, a meta-analysis of domestic and foreign articles on the use of Danio rerio in toxicological, pharmacological, embryological, and other areas of research has been carried out. Results and discussion. Danio rerio (Zebrafish) can be used in many areas of preclinical drug research. Particularly interesting is their use for modeling novelty stress and experimental depression. Conclusion. Danio rerio is a universal model object, which makes it possible to carry out research of various pharmacological preparations in a cost-effective manner before they are tested on other animal models.