PREVENTIVE EPIGENETIC MECHANISMS OF FUNCTIONAL FOODS FOR TYPE 2 DIABETES

  • Arshed A. Kuchay Saint Petersburg State Pediatric Medical University; City Hospital № 14 https://orcid.org/0000-0002-7974-9369
  • Alexander N. Lipin City Hospital № 14; Military Medical Academy named after S.M. Kirov
  • Natalia R. Karelina Saint Petersburg State Pediatric Medical University
  • Nikita N. Gruzdev City Hospital № 14
  • Kirill A. Atmatzas City Hospital № 14
  • Linard Yu. Artyukh Saint Petersburg State Pediatric Medical University
  • Vsevolod M. Mironov National Medical Research Center of Cardiology named after Academician E.I. Chazov
  • Farit D. Akkubakov Saint Petersburg State Pediatric Medical University
  • Mikhail Giuseppe L. Oppedisano Saint Petersburg State Pediatric Medical University
Keywords: diabetes, epigenetic inheritance, healthy food, transition from generation to generation

Abstract

Type 2 diabetes (T2D) is a growing global health problem that requires new and effective prevention and management strategies. Recent research has highlighted the role of epigenetic changes in the development and progression of T2D, and the potential of functional foods as a complementary therapy for the disease. This review aims to provide an overview of the current state of knowledge on the preventive epigenetic mechanisms of functional foods in T2D. We provide background information on T2D and its current treatment approaches, an explanation of the concept of epigenetics, and an overview of the different functional foods with demonstrated preventive epigenetic effects in T2D. We also discuss the epigenetic mechanisms by which these functional foods prevent or manage T2D, and the studies that have investigated their preventive epigenetic effects. In addition, we revisit works on the beneficial influence of functional foods against the programming and complications of parentally-triggered offspring diabetes. We also suggest, albeit based on scarce data, that epigenetic inheritance mechanistically mediates the impacts of functional nutrition against the metabolic risk of diabetes in offspring. Finally, our review highlights the importance of considering the preventive epigenetic mechanisms of functional foods as a potential avenue for the development of new prevention and management strategies for T2D.

Author Biography

Arshed A. Kuchay, Saint Petersburg State Pediatric Medical University; City Hospital № 14

Сardiovascular surgeon, clinical researcher of the City Limb Salvage Center. Senior lecturer at the Department of human anatomy Saint Petersburg State Pediatric Medical University

References

World Health Organization. Who — The Top 10 Causes of Death. 24 Maggio. World Health Organization: Geneva, Switzerland. 2018: 1–7.

Hameed I., Masoodi S.R., Mir S.A. et al. Type 2 Diabetes Mellitus: From a Metabolic Disorder to an Inflammatory Condition. World J. Diabetes. 2015. 6: 598.

Deshpande A.D., Harris-Hayes M., Schootman M. Epidemiology of Diabetes and Diabetes-Related Complications. Phys. Ther. 2008. 88: 1254–64.

Petrie J.R., Guzik T.J., Touyz R.M. Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and vascular Mechanisms. Can. J. Cardiol. 2018. 34: 575–84.

Magkos F., Yannakoulia M., Chan J.L., Mantzoros C.S. Management of the Metabolic Syndrome and Type 2 Diabetes through Lifestyle Modification. Annu. Rev. Nutr. 2009. 29: 223–56.

Asif M. The Prevention and Control the Type-2 Diabetes by Changing Lifestyle and Dietary Pattern. J. Educ. Health Promot. 2014. 3: 1.

Chaudhury A., Duvoor C., Reddy Dendi V.S. et al. Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management. Front. Endocrinol. 2017. 8: 6.

Sola D., Rossi L., Schianca G.P.C. et al. Sulfonylureas and Their Use in Clinical Practice. Arch. Med. Sci. 2015. 11: 840–8.

Alkhatib A., Tsang C., Tiss A. et al. Functional Foods and Lifestyle Approaches for Diabetes Prevention and management. Nutrients. 2017. 9: 1310.

Kolb H., Martin S. Environmental/Lifestyle Factors in the Pathogenesis and Prevention of Type 2 Diabetes. Bmc med. 2017. 15: 131.

Abubakar B., Zawawi N., Omar A.R., Ismail M. Predisposition to Insulin Resistance and Obesity due to Staple Consumption of Rice: Amylose Content versus Germination Status. Plos One. 2017.12: e0181309.

Chang S.A. Smoking and Type 2 Diabetes Mellitus. Diabetes Metab. J. 2012. 36: 399–403.

Toorie A.M., Vassoler F.M., Qu F. et al. A History of Opioid Exposure in Females Increases the Risk of Meta­bolic Disorders in Their Future Male Offspring. Addict. Biol. 2021. 26: 12856.

Uusitupa M. Lifestyles Matter in the Prevention of Type 2 Diabetes. Diabetes Care. 2002. 25: 1650–1.

Silva D.A.S., Naghavi M., Duncan B.B. et al. Physical Inactivity as Risk Factor for Mortality by Diabetes Mellitus in Brazil in 1990, 2006, and 2016. Diabetol. Metab. Syndr. 2019. 11: 23.

Al-Yasari A., Jabbar. S., Cabrera M.A. et al. Preconception Alcohol Exposure Increases the Susceptibility to Diabetes in the Offspring. Endocrinology. 2021. 162: bqaa188.

Holst C., Becker U., Jørgensen M.E. et al. Alcohol Drinking Patterns and Risk of Diabetes: A Cohort Study of 70,551 Men and Women from the General Danish Population. Diabetologia. 2017. 60: 1941–50.

Da Porto A., Cavarape A., Colussi G. et al. Polyphenols Rich Diets and Risk of Type 2 Diabetes. Nutrients. 2021. 13: 1445.

Tertsunen H.M., Hantunen S., Tuomainen T.P., Virtanen J.K. Adherence to a Healthy Nordic Diet and Risk of Type 2 Diabetes among Men: The Kuopio Ischae­mic Heart Disease Risk Factor Study. Eur. J. Nutr. 2021. 60: 3927–34.

Shu L., Shen X.M., Li C. et al. Dietary Patterns Are Associated with Type 2 Diabetes Mellitus among Middle-Aged Adults in Zhejiang Province, China. Nutr. J. 2017. 16: 81.

Imam M.U., Ishaka A., Ooi D.J. et al. Germinated Brown Rice Regulates Hepatic Cholesterol Metabolism and Cardiovascular Disease Risk in Hypercholesterolaemic Rats. J. Funct. Foods. 2014. 8: 193–203.

Stegemann R., Buchner D.A. Transgenerational Inheri­tance of Metabolic Disease. Semin. Cell Dev. Biol. 2015. 43: 131–40.

Steyn N.P., Mann J., Bennett P.H., et al. Diet, Nutrition and the Prevention of Type 2 Diabetes. Public Health Nutr. 2004. 7: 147–65.

Abubakar B., Yakasai H.M., Zawawi N., Ismail M. Compositional Analyses of White, Brown and Germinated Forms of Popular Malaysian Rice to Offer Insight into the Growing Diet-Related Diseases. J. Food Drug Anal. 2018. 26: 706–15.

Kusuyama J., Makarewicz N.S., Albertson B.G. et al. Maternal Exercise-Induced Sod3 Reverses the Deleterious Effects of Maternal High-Fat Diet on Offspring Metabolism Through Stabilization of H3k4me3 and Protection Against Wdr82 Carbonylation. Diabetes. 2022. 71: 1170–81.

Liu S., Manson J.E., Stampfer M.J. et al. A Prospective Study of Whole-Grain Intake and Risk of Type 2 Diabetes Mellitus in Us Women. Am. J. Public Health. 2000. 90:1409–15.

Maki K.C., Phillips A.K. Dietary Substitutions for Refined Carbohydrate That Show Promise for Reducing Risk of Type 2 Diabetes in Men and Women. J. Nutr. 2015. 145: 159s–63s.

Samra R.A., Anderson G.H. Insoluble Cereal Fiber Reduces Appetite and Short-Term Food Intake and Glycemic Response to Food Consumed 75 Min Later by Healthy Men. Am. J. Clin. Nutr. 2007. 86: 972–9.

Arihara K. Functional Foods. Encycl. Meat Sci. 2014. 2: 32–6.

Schwingshackl L., Hoffmann G., Lampousi A.M. et al. Food Groups and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Prospective Studies. Eur. J. Epidemiol. 2017. 32: 363–75.

Published
2023-10-20
How to Cite
Kuchay, A. A., Lipin, A. N., Karelina, N. R., Gruzdev, N. N., Atmatzas, K. A., Artyukh, L. Y., Mironov, V. M., Akkubakov, F. D., & Oppedisano, M. G. L. (2023). PREVENTIVE EPIGENETIC MECHANISMS OF FUNCTIONAL FOODS FOR TYPE 2 DIABETES. FORCIPE, 6(1), 4-16. Retrieved from https://ojs3.gpmu.org/index.php/forcipe/article/view/5674
Issue
Vol 6 No 1 (2023)
Section
Статьи