LYMPHOSCINTIGRAPHY AND SPECT/CT ADVANTAGES IN VERIFYING LYMPHORRHEA: A CLINICAL CASE EXHAMPLE OF EXTRA-ABDOMINAL DESMOID FIBROMA TREATMENT

  • T.V. Makurova City Mariinsky Hospital. Liteyny Ave., 56, Saint Petersburg, Russian Federation, 191014 https://orcid.org/0000-0003-4337-9738
  • P.I. Simeshchenko City Mariinsky Hospital. Liteyny Ave., 56, Saint Petersburg, Russian Federation, 191014
Keywords: desmoid fibroma, lymphorrhea, lymphoscintigraphy, 99mTc-sulfur colloid, SPECT/CT

Abstract

Objective. To demonstrate the effectiveness of lymphoscintigraphy and SPECT/CT in identification of the lymphorrhea in posttreatment of extra-abdominal desmoid fibroma period.
Materials and methods. 38-year-old patient complained on the flaccid granulating wound of the anterior surface of the right thigh. There was a history of surgical treatment of extra-abdominal
desmoid fibroma located at the inner surface of the middle third of right thigh. Postoperative course of radiation therapy; neurolysis of the sciatic and femoral nerves. Eventually, she suffered
from active liquid discharge in the wound area with the bandage getting wet at the posttreatment period. The static lymphoscintigraphy and regional SPECT/CT of the lower extremities and pelvis
were performed after subcutaneous injection of 99mTc-sulfur colloid. Results. Lymphoscintigraphy showed a failure of the lymphatic vessels drainage function at the right lower limb. Moreover, shunt formation between the superficial and deep lymphatic tracts was revealed. Based on the results of the hybrid imaging study the lymphorrhea in the region of the middle third of the right thigh was confirmed. Conclusion. SPECT/CT with 99mTc-sulfur colloid is a highly informative method for verifying lymphorrhea, improves the diagnostic accuracy of indirect lymphoscintigraphy, and makes it possible to differentiate the superficial and deep lymphatic tracts.

References

Bertani E, Testori A, Chiappa A, Misitano P, Biffi R, Viale G, Mazzarol G, De Pas T, Botteri E, Contino G, Verrecchia F, Bazolli B, Andreoni B. Recurrence and prognostic factors in patients with aggressive fibromatosis. The role of radical surgery and its limitations. World J Surg Oncol. 2012;10:184.

Bonvalot S, Eldweny H, Haddad V, Rimareix F, Missenard G, Oberlin O, Vanel D, Terrier P, Blay JY, Le Cesne A, Le Péchoux C. Extra-abdominal primary fibromatosis: aggressive management could be avoided in a subgroup of patients. Eur J Surg Oncol. 2008;34(4):462–468.

Cheon SS, Cheah AY, Turley S, Nadesan P, Poon R, Clevers H, Alman BA. beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci U S A. 2002;99(10):6973–8. 10.1073/pnas.102657399.

Clark SK, Neale KF, Landgrebe JC, Phillips RK. Desmoid tumours complicating familial adenomatous polyposis. Br J Surg. 1999;86(9):1185–9.

Eastley N, Aujla R, Silk R, Richards CJ, McCulloch TA, Esler CP, Ashford RU. Extra-abdominal desmoid fibromatosis--a sarcoma unit review of practice, long term recurrence rates and survival. Eur J Surg Oncol. 2014;40(9):1125–30.

Eastley N, McCulloch T, Esler C, Hennig I, Fairbairn J, Gronchi A, Ashford R. Extra-abdominal desmoid fibromatosis: a review of management, current guidance and unanswered questions. Eur J Surg Oncol. 2016;42(7):1071–83.

Fiore M, MacNeill A, Gronchi A, Colombo C. Desmoid-type fibromatosis: evolving treatment standards. Surg Oncol Clin N Am. 2016;25(4):803–26.

Fisher C, Thway K. Aggressive fibromatosis. Pathology. 2014;46(2):135–40.

Fletcher C.D.M., Unni K.K., Mertens F. (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press: Lyon 2002

Garcia-Ortega D. Y., Martín-Tellez K. S., Cuellar-Hubbe M., et al. Desmoid-type fibromatosis. Cancers. 2020;12(7):p. 1851.

Galateau-Salle F, Churg A, Roggli V, Travis WD; World Health Organization Committee for Tumors of the Pleura. The 2015 World Health Organization classification of tumors of the pleura: advances since the 2004 classification. J Thorac Oncol. 2016;11(2):142–54.

Gronchi A, Colombo C, Le Péchoux C, Dei Tos AP, Le Cesne A, Marrari A, Penel N, Grignani G, Blay JY, Casali PG, Stoeckle E, Gherlinzoni F, Meeus P, Mussi C, Gouin F, Duffaud F, Fiore M, Bonvalot S. Sporadic desmoid-type fibromatosis: a stepwise approach to a non-metastasising neoplasm-a position paper from the Italian and the French sarcoma group. Ann Oncol. 2014;25(3):578–583.

Gronchi A, Casali PG, Mariani L, Lo Vullo S, Colecchia M, Lozza L, Bertulli R, Fiore M, Olmi P, Santinami M, Rosai J. Quality of surgery and outcome in extra-abdominal aggressive fibromatosis: a series of patients surgically treated at a single institution. J Clin Oncol. 2003;21(7):1390–1397.

Goodlad JR, Fletcher CD, Smith MA. Surgical resection of primary soft-tissue sarcoma. Incidence of residual tumour in 95 patients needing re-excision after local resection. J Bone Joint Surg Br. 1996;78(4):658–61.

Goy BW, Lee SP, Eilber F, Dorey F, Eckardt J, Fu YS, Juillard GJ, Selch MT. The role of adjuvant radiotherapy in the treatment of resectable desmoid tumors. Int J Radiat Oncol Biol Phys. 1997;39(3):659–65.

Huang K, Fu H, Shi YQ, Zhou Y, Du CY. Prognostic factors for extra-abdominal and abdominal wall desmoids: a 20-year experience at a single institution. J Surg Oncol. 2009;100(7):563–569

Kasper B, Baumgarten C, Garcia J, Bonvalot S, Haas R, Haller F, Hohenberger P, Penel N, Messiou C, van der Graaf WT, Gronchi A, Desmoid Working Group. An update on the management of sporadic desmoid-type fibromatosis: a European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG). Ann Oncol. 2017;28(10):2399–408.

Keus RB, Nout RA, Blay JY, et al. Results of a phase II pilot study for moderate dose radiotherapy for inoperable desmoidtype fibromatosis: an EORTC STBSG and ROG study (EORTC 62991-22998). Ann Oncol. 2013;24(10):2672–6.

Leithner A, Gapp M, Leithner K, Radl R, Krippl P, Beham A, Windhager R. Margins in extra-abdominal desmoid tumors: a comparative analysis. J Surg Oncol. 2004;86(3):152–156.

Lewis JJ, Boland PJ, Leung DH, Woodruff JM, Brennan MF (1999). The enigma of desmoid tumors. Ann Surg 229: 866-872.

Mankin H. J., Hornicek F. J., Springfield D. S. Extra-abdominal desmoid tumors: a report of 234 cases. Journal of Surgical Oncology. 2010;102(5):380–384.

Merchant NB, Lewis JJ, Woodruff JM, Leung DH, Brennan MF (1999). Extremity and trunk desmoid tumors: a multifactorial analysis of outcome. Cancer 86: 2045-2052.

Molloy A. P., Hutchinson B., O’Toole G. C. Extra-abdominal desmoid tumours: a review of the literature. Sarcoma. 2012;2012:9.

Müller J. Ueber den feineren Bau und die Formen der krankhaften Geschwülste. Berlin: De Gruyter; 1838.

Pierluigi Cuomo, Guido Scoccianti, Alberto Schiavo et al. Extra-abdominal desmoid tumor fibromatosis: a multicenter EMSOS study. BMC Cancer. 2021; 21: 437.

Reitamo JJ, Hayry P, Nykyri E, Saxen E (1982). The desmoid tumor. I. Incidence, sex-, age- and anatomical distribution in the Finnish population. Am J Clin Pathol 77: 665-673.

Sørensen A, Keller J, Nielsen OS, Jensen OM. Treatment of aggressive fibromatosis: a retrospective study of 72 patients followed for 1-27 years. Acta Orthop Scand. 2002;73(2):213-219.

Teixeira LE, Arantes EC, Villela RF, Soares CB, Costa RB, Andrade MA. Extra-abdominal desmoid tumor: local recurrence and treatment options. Acta Ortop Bras. 2016;24(3):147–50.

van Broekhoven DL, Grünhagen DJ, den Bakker MA, van Dalen T, Verhoef C. Time trends in the incidence and treatment of extra-abdominal and abdominal aggressive fibromatosis: a population-based study. Ann Surg Oncol. 2015;22(9):2817–23.

Villa G, Campisi CC, Ryan M, Boccardo F, Di Summa P, Frascio M, Sambuceti G, Campisi C. Procedural Recommendations for Lymphoscintigraphy in the Diagnosis of Peripheral Lymphedema: the Genoa Protocol. Nucl Med Mol Imaging. 2019 Feb;53(1):47-56.

Wagstaff MJ, Raurell A, Perks AG. Multicentric extra-abdominal desmoid tumours. Br J Plast Surg. 2004;57(4):362–5.

Jose M. Lasso. Lympho-SPECT/CT as a tool to evaluate postoperative outcomes after LVA for lymphedema repair. Plast Aesthet Res 2020;7:30.

Published
2024-07-01
How to Cite
Makurova, T., & Simeshchenko, P. (2024). LYMPHOSCINTIGRAPHY AND SPECT/CT ADVANTAGES IN VERIFYING LYMPHORRHEA: A CLINICAL CASE EXHAMPLE OF EXTRA-ABDOMINAL DESMOID FIBROMA TREATMENT. Medicine: Theory and Practice, 8(4), 71-78. https://doi.org/10.56871/MTP.2023.72.13.010
Section
Статьи