КЛИНИКО-ПАТОГЕНЕТИЧЕСКОЕ ЗНАЧЕНИЕ ГИПОТЕРМИИ

E.V. Shrayner; A.I. Khavkin; K.M. Nikolaychuk; A.S. Veremenko; I.D. Levchenko; P.Ya. Platonova; M.F. Novikova; A.S. Tumas; E.E. Vergunova; D.A. Lukichev; D.A. Sergeev

doi:10.56871/MTP.2025.91.98.006

E.V. Shrayner Novosibirsk State University. 1 Pirogov str., Novosibirsk 630090 Russian Federation
A.I. Khavkin Research Clinical Institute of Childhood. 62 Bolshaya Serpukhovskaya str., Moscow 115093 Russian Federation https://orcid.org/0000-0001-7308-7280
K.M. Nikolaychuk Novosibirsk State University. 1 Pirogov str., Novosibirsk 630090 Russian Federation
A.S. Veremenko Novosibirsk State University. 1 Pirogov str., Novosibirsk 630090 Russian Federation
I.D. Levchenko Novosibirsk State University. 1 Pirogov str., Novosibirsk 630090 Russian Federation
P.Ya. Platonova Novosibirsk State University. 1 Pirogov str., Novosibirsk 630090 Russian Federation
M.F. Novikova Novosibirsk State University. 1 Pirogov str., Novosibirsk 630090 Russian Federation
A.S. Tumas Novosibirsk State University. 1 Pirogov str., Novosibirsk 630090 Russian Federation
E.E. Vergunova Novosibirsk State University. 1 Pirogov str., Novosibirsk 630090 Russian Federation
D.A. Lukichev Novosibirsk State University. 1 Pirogov str., Novosibirsk 630090 Russian Federation
D.A. Sergeev Novosibirsk State University. 1 Pirogov str., Novosibirsk 630090 Russian Federation

DOI: https://doi.org/10.56871/MTP.2025.91.98.006

Keywords: hypothermia, hibernation, haemostasis, coagulation, fibrinolysis, platelet haemostasis

Abstract

The article deals with the mechanisms of hypothermia influence on the haemostasis system, as well as adaptation of the haemostasis system in animals in the state of hibernation. The main attention is paid to the changes in the primary and secondary links of haemostasis, as well as in the fibrinolysis system at decreasing body temperature. Phenomena of slowing down of enzymatic activity in the blood coagulation cascade, changes in the morphology and function of platelets are considered. Particular attention is paid to the unique mechanisms of animal adaptation to the state of reduced temperature, including a decrease in the level of coagulation factors and activation of the fibrinolytic system during hibernation. The article also discusses potential medical applications of the knowledge gained, including improving platelet storage and preservation methods, developing strategies for managing therapeutic hypothermia, and new approaches to treating coagulopathies. Additionally, this article discusses the role of hypothermia in the regulation of haemostasis in patients undergoing severe trauma or major surgery.

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CLINICAL AND PATHOGENETIC SIGNIFICANCE OF HYPOTHERMIA

Abstract

References

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