ГЛУБОКИЕ ЭВТЕКТИЧЕСКИЕ РАСТВОРИТЕЛИ — НОВЫЙ СПОСОБ ТРАНСДЕРМАЛЬНОЙ ДОСТАВКИ ЛЕКАРСТВ
Аннотация
Системы трансдермальной доставки лекарственных средств имеют ряд преимуществ благодаря неинвазивному введению и особенностям фармакокинетики, что делает данный способ крайне привлекательным в педиатрической практике. Фармакокинетические преимущества заключаются в повышении биологической доступности из-за отсутствия эффекта первичного прохождения через печень, равномерного поступления действующего вещества в системный кровоток, благодаря чему кривая концентрации лекарственного вещества приобретает более равномерный характер. На данный момент в мире в качестве систем трансдермальной доставки используются пластыри, однако глобальные сложности правоприменительной практики вывода препаратов для акушерской и педиатрической аудитории на рынок лимитируют возможности создания трансдермальных терапевтических систем. В данном обзоре рассмотрены системы трансдермальной доставки лекарственных средств на основе глубоких эвтектических растворителей. Благодаря своим уникальным свойствам, таким как простота синтеза, низкая токсичность и стоимость, высокая стабильность и биосовместимость, глубокие эвтектические растворители являются привлекательными системами доставки активных фармацевтических субстанций для применения в педиатрии.
Литература
Abbott A.P. et al. Novel solvent properties of choline chloride/urea mixtures. Chemical Communications. 2003; 1: 70–1.
Abranches D.O. et al. Phenolic hydrogen bond donors in the formation of non-ionic deep eutectic solvents: the quest for type V DES. Chemical Communications. 2019; 69(55): 10253–6.
Amjadi M., Mostaghaci B., Sitti M. Recent Advances in Skin Penetration Enhancers for Transdermal Gene and Drug Delivery. Current Gene Therapy. 2017; 2(17).
Andaloussi S.El. et al. Extracellular vesicles: biology and emerging therapeutic opportunities. Nature reviews. Drug discovery. 2013; 5(12): 347–57.
Araújo-Filho H.G. de et al. Anticancer activity of limonene: A systematic review of target signaling pathways. Phytotherapy Research. 2021; 9(35): 4957–70.
Aroso I.M. et al. Design of controlled release systems for THEDES — Therapeutic deep eutectic solvents, using supercritical fluid technology. International Journal of Pharmaceutics. 2015; 1–2(492): 73–9.
Bishnupuri K.S. et al. IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis. Cancer research. 2019; 6(79): 1138–50.
Chen X. et al. Electroporation-enhanced transdermal drug delivery: Effects of logP, pKa, solubility and penetration time. European Journal of Pharmaceutical Sciences. 2020; 151: 105410.
Correia R. et al. Improved storage of influenza HA-VLPs using a trehalose-glycerol natural deep eutectic solvent system. Vaccine. 2021; 24(39): 3279–86.
Dai Y. et al. Natural deep eutectic solvents as a new extraction media for phenolic metabolites in carthamus tinctorius L. Analytical Chemistry. 2013; 13(85): 6272–8.
Dai Y. et al. Tailoring properties of natural deep eutectic solvents with water to facilitate their applications. Food Chemistry. 2015; 187: 14–9.
Dhal S. et al. Facile transdermal delivery of upconversion nanoparticle by iontophoresis-responsive magneto-upconversion oleogel. Nano Express. 2020; 1(1): 010012.
Dhal S., Pal K., Giri S. Transdermal Delivery of Gold Nanoparticles by a Soybean Oil-Based Oleogel under Iontophoresis. ACS Applied Bio Materials. 2020; 10 (3): 7029–39.
Gusachenko O.N., Zenkova M.A., Vlassov V.V. Nucleic acids in exosomes: Disease markers and intercellular communication molecules. Biochemistry (Moscow). 2013; 1(78): 1–7.
Hadgraft J., Whitefield M., Rosher P.H. Skin penetration of topical formulations of ibuprofen 5%: an in vitro comparative study. Skin pharmacology and applied skin physiology. 2003; 3(16): 137–42.
Han D. et al. 4D Printing of a Bioinspired Microneedle Array with Backward-Facing Barbs for Enhanced Tissue Adhesion. Advanced Functional Materials. 2020; 11(30): 1909197.
Harirforoosh S., Asghar W., Jamali F. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2013; 5(16): 821–47.
Jeong W.Y. et al. Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia. Biomaterials Research. 2019; 1(23): 1–10.
Kim H.M. et al. Transdermal drug delivery using disk microneedle rollers in a hairless rat model. International Journal of Dermatology. 2012; 7(51): 859–63.
Kovács A. et al. Modeling the Physicochemical Properties of Na-
tural Deep Eutectic Solvents. ChemSusChem. 2020; 15(13): 3789–3804.
Kumar Harwansh R. et al. Nanoemulsions as vehicles for transdermal delivery of glycyrrhizin. Brazilian Journal of Pharmaceutical Sciences. 2011; 4(47): 769–78.
Lee M.S. et al. Natural deep eutectic solvents as a storage medium for human interferon-α2: a green and improved strategy for room-temperature biologics. Journal of Industrial and Engineering Chemistry. 2018; 65: 343–8.
Lee Y. et al. Localized Delivery of Theranostic Nanoparticles and High-Energy Photons using Microneedles-on-Bioelectronics. Advanced Materials. 2021; 24 (33): 2100425.
Li Y. et al. Improving the hypoglycemic effect of insulin via the nasal administration of deep eutectic solvents. International journal of pharmaceutics. 2019; 569.
Li Y., Guo L., Lu W. Laser ablation-enhanced transdermal drug delivery. Photonics and Lasers in Medicine. 2013; 4(2): 315–22.
Li Z., Lee P. I. Investigation on drug solubility enhancement using deep eutectic solvents and their derivatives. International journal of pharmaceutics. 2016; 1–2(505): 283–8.
Lin C.H., Aljuffali I.A., Fang J.Y. Lasers as an approach for promoting drug delivery via skin. Expert Opinion on Drug Delivery. 2014; 4(11): 599–614.
Liu M. et al. Novel amorphous solid dispersion based on natural deep eutectic solvent for enhancing delivery of anti-tumor RA-XII by oral administration in rats. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021; 166.
Lu C. et al. Significantly improving the solubility of non-steroidal anti-inflammatory drugs in deep eutectic solvents for potential non-aqueous liquid administration. MedChemComm. 2016; 5(7): 955–9.
Martínez-Reyes I., Chandel N.S. Cancer metabolism: looking forward. Nature Reviews Cancer. 2021; 10(21): 669–80.
Maugeri Z., Domínguez De María P. Novel choline-chloride-based deep-eutectic-solvents with renewable hydrogen bond donors: levulinic acid and sugar-based polyols. RSC Advances. 2011; 2(2): 421–5.
Md Moshikur R. et al. Biocompatible ionic liquids and their applications in pharmaceutics. Green Chemistry. 2020; 23(22): 8116–39.
Mitragotri S. Sonophoresis: Ultrasound-mediated transdermal drug delivery. Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. 2017: 3–14.
Moarefian M. et al. Modeling iontophoretic drug delivery in a microfluidic device. Lab on a Chip. 2020; 18(20): 3310–21.
Motlagh S.R. et al. COSMO-RS Based Prediction for Alpha-Linolenic Acid (ALA) Extraction from Microalgae Biomass Using Room Temperature Ionic Liquids (RTILs). Marine Drugs. 2020; 2(18): 108.
Pandey P. et al. Nanoemulsion: A Novel Drug Delivery Approach for Enhancement of Bioavailability. Recent patents on nanotechnology. 2020; 4 (14): 276–93.
Parhi R., Mandru A. Enhancement of skin permeability with thermal ablation techniques: concept to commercial products. Drug delivery and translational research. 2021; 3(11): 817–41.
Park J. et al. Enhanced Transdermal Drug Delivery by Sonophoresis and Simultaneous Application of Sonophoresis and Iontophoresis. AAPS PharmSciTech. 2019; 3 (20): 1–7.
Pedro S. N. et al. Deep eutectic solvents comprising active pharmaceutical ingredients in the development of drug delivery systems. Expert opinion on drug delivery. 2019; 5(16): 497–506.
Pereira C. V. et al. Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents. Scientific Reports. 2019; 1(9): 1–11.
Pereira R. et al. Current Status of Amino Acid-Based Permeation Enhancers in Transdermal Drug Delivery. Membranes. 2021; 5(11).
Pierucci S. et al. Potential of Choline Chloride-Based Natural Deep Eutectic Solvents (NaDES) in the Extraction of Microalgal Metabolites. CHEMICAL ENGINEERING TRANSACTIONS. 2017; 57.
Pradeepkumar P. et al. Targeted Delivery of Doxorubicin in HeLa Cells Using Self-Assembled Polymeric Nanocarriers Guided by Deep Eutectic Solvents. ChemistrySelect. 2021; 28 (6): 7232–41.
Qi Q.M. et al. Comparison of Ionic Liquids and Chemical Permeation Enhancers for Transdermal Drug Delivery. Advanced Functional Materials. 2020; 45 (30): 2004257.
Radošević K. et al. Evaluation of toxicity and biodegradability of choline chloride based deep eutectic solvents. Ecotoxicology and Environmental Safety. 2015; 112: 46–53.
Ramos A.P., Bouwstra J.A., Lafleur M. Very long chain lipids favor the formation of a homogeneous phase in stratum corneum model membranes. Langmuir. 2020; 46(36): 13899–907.
Santos de Almeida T. et al. Choline- versus imidazole-based ionic liquids as functional ingredients in topical delivery systems: cytotoxicity, solubility, and skin permeation studies. Drug development and industrial pharmacy. 2017; 11(43): 1858–65.
Smith E.L., Abbott A.P., Ryder K.S. Deep Eutectic Solvents
(DESs) and Their Applications. Chemical Reviews. 2014; 21(114): 11060–82.
Sokołowska E., Błachnio-Zabielska A.U. A Critical Review of
Electroporation as A Plasmid Delivery System in Mouse Skeletal Muscle. International Journal of Molecular Sciences. 2019; 11(20): 2776.
Vaidya A., Mitragotri S. Ionic liquid-mediated delivery of in-
sulin to buccal mucosa. Journal of Controlled Release. 2020; 327: 26–34.
Wu H. et al. Improved transdermal permeability of ibuprofen by ionic liquid technology: Correlation between counterion structure and the physicochemical and biological properties. Journal of Molecular Liquids. 2019; 283: 399–409.
Zdanowicz M., Wilpiszewska K., Spychaj T. Deep eutectic solvents for polysaccharides processing. A review. Carbohydrate Polymers. 2018; 200: 361–80.
WO2019122329 LIQUID VACCINES OF LIVE ENVELOPED
VIRUSES [Электронный ресурс]. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019122329 (дата обращения: 04.10.2023).
Copyright (c) 2023 Russian Biomedical Research (Российские биомедицинские исследования)
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.
