DEEP EUTECTIC SOLVENTS — A NEW METHOD FOR TRANSDERMAL DRUG DELIVERY
Abstract
Transdermal drug delivery systems are more advantageous due to non-invasive treatment and pharmacokinetics, which makes / makes this method attractive in pediatric practice. Pharmacokinetic advantages consist of increasing bioavailability due to the absence of the effect of primary passage through the liver and uniform intake of the active substance into the systemic circulation, which is why the concentration curve of the medicinal substance is more uniform. Currently, plasters are used as transdermal delivery systems in the world, but the legal difficulties of commercialization of drugs for obstetric and pediatric audiences limit the possibilities of using transdermal therapeutic systems. In this review, transdermal drug delivery systems based on deep eutectic solvents are discussed. Due to unique properties such as ease of synthesis, low toxicity and cost, high stability and biocompatibility, deep eutectic solvents are attractive delivery systems for active pharmaceutical substances for use in pediatrics.
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