INFLUENCE OF A FREQUENCY-MODULATED ELECTRIC FIELD SIGNAL ON THE ANALGESIC ACTIVITY OF XYLAZINE IN FULL-THICKNESS SKIN WOUNDS ON THE BACKGROUND OF POLYTRAUMA

Abstract

In an experimental study, the effect of a frequency -modulated electric field signal (FMEFS) on the analgesic activity of xylazine was evaluated. Mechanical polytrauma in 40 outbred rats of both sexes was reproduced by placing laboratory animals in a special rotating drum at a speed of 40 rpm for 30 minutes. After 20 min minutes rotation rodents were inflicted with full -thickness skin wounds of about 5 % b.f. on the back with a scalpel. The effect of the effect of a frequency -modulated electric field signal on the analgesic activity of xylazine was carried out 10 and 60 minutes after its administration at a dose of 20 mg/kg. The comparison was carried out with the control group - the isolated use of xylazine at the same time in animals with similar injuries. It was found that with the combined effect of xylazine and a frequency -modulated signal of the electric floor, an increase in the pain threshold was noted after 10 and 60 minutes, respectively, by 40 % (p < 0.05) and 2 times (p < 0.01). A similar analgesic effect was found with the introduction of the minimum dose of the anesthetic substance - 5 mg/kg. The results obtained testify to the high efficiency of the frequency -modulated electric field signal, as a way to increase the analgesic activity of xylazine in medium therapeutic and minimal dosages. The results of the work show the need for further study and the possibility of using FMEFS in everyday clinical practice, incl. in surgery.