USE OF GEL OF RARELY CROSS-LINKED ACRYLIC POLYMERS WITH A COMPLEX OF NATURAL ANTIMICROBIAL PEPTIDES FLIP-7 IN THE TREATMENTOF BORDERLINE SKIN BURNS

Abstract

To date, a significant number of methods and techniques have been developed for the treatment of borderline burn wounds, including a wide range of both drugs and physiotherapeutic effects. However, most of them do not have the ability to completely suppress the activity of microorganisms growing in wounds. The latter is often represented by a combination of both gram -positive and gram -negative strains that are resistant to most antibacterial drugs. This is due to the evolutionary mechanisms of adaptation of microorganisms, which allowed them to develop a variety of protection systems in the form of the formation of polymicrobial associates and biological films, the traditional methods of influence on which are ineffective. The use of a gel of rarely cross -linked acrylic polymers with a complex of natural antimicrobial peptides FLIP-7 can become one of the promising ways to solve microbial resistance. Its application on the wound surface provides active elimination of pathogenic microflora from the damaged area and creates optimal conditions for reparative regeneration. The introduction of hydrogels with FLIP7 into the system of care for patients with borderline skin burns will improve the results of treatment for this category of patients.