MYCOPLASMAS. BIOLOGICAL PROPERTIES (LECTURE)

  • D.P. Gladin Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100 https://orcid.org/0000-0003-4957-7110
  • N.S. Kozlova North-Western Medical University named after I.I. Mechnikov. Kirochnaya 41, Saint Petersburg, Russian Federation, 191015
  • I.A. Edelstein Research Institute of Antimicrobial Chemotherapy. Kirova str., 46A, Smolensk, Russian Federation, 214019
  • A.A. Martinovich Research Institute of Antimicrobial Chemotherapy. Kirova str., 46A, Smolensk, Russian Federation, 214019
  • D.G. Borukhovich Skin and venereological dispensary № 11. Tchaikovsky st., 1, Saint Petersburg, Russian Federation, 191187
  • N.P. Kirillova Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
  • A.V. Zachinyaeva Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
  • A.N. Andreeva Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
  • M.Yu. Komissarova Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
DOI: https://doi.org/10.56871/RBR.2023.58.16.012
Keywords: Mycoplasmas, Mycoplasma pneumoniaе, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealyticum, biological properties, virulence factors

Abstract

Mycoplasmas are a unique group of prokaryotes, a characteristic feature of which is the absence of a cell wall. The features of mycoplasmas also include a minimal set of organelles, the presence of sterols in the cytoplasmic membrane, which microorganisms themselves cannot synthesize, the smallest known self-replicating genome structure, as well as membrane parasitism. The growing interest in these microorganisms is due to a number of factors: the variety of biological properties, the undoubted relevance of the pathology caused by them and many unsolved problems in the world health system. Mycoplasmas have received the greatest importance as pathogens of urogenital and respiratory infections, however, a wide range of virulence factors of these microorganisms, features of their interaction with the cellular and humoral immunity of the host causes damage to other organs associated with autoimmune mechanisms and hypersensitivity of the macroorganism. There is information about possible involvement of mycoplasmas in the process of carcinogenesis through the release of the DnaK protein, which impairs the ability of a mycoplasma-infected cell to repair DNA damage by reducing the activity of important cellular proteins such as p53. The ecological plasticity of mycoplasmas, a wide range of hosts and their ubiquity, which actualizes the problem of mycoplasma infections for almost any geographical region.

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Published
2024-05-16
How to Cite
Gladin, D., Kozlova, N., Edelstein, I., Martinovich, A., Borukhovich, D., Kirillova, N., Zachinyaeva, A., Andreeva, A., & Komissarova, M. (2024). MYCOPLASMAS. BIOLOGICAL PROPERTIES (LECTURE). Russian Biomedical Research, 8(4), 103-115. https://doi.org/10.56871/RBR.2023.58.16.012
Issue
Vol 8 No 4 (2023)
Section
Статьи

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