RISK FACTORS FOR ADVERSE OUTCOMES OF COVID-19 PNEUMONIA IN PATIENTS INTENSIVE CARE UNIT WITH COMORBID DISEASES

  • E.Yu. Soloveychik Bashkir State Medical University. 3 Lenin str., Ufa Republic of Bashkortostan 450008 Russian Federation https://orcid.org/0000-0001-9180-5258
  • I.I. Lutfarakhmanov Bashkir State Medical University. 3 Lenin str., Ufa Republic of Bashkortostan 450008 Russian Federation
  • P.I. Mironov Bashkir State Medical University. 3 Lenin str., Ufa Republic of Bashkortostan 450008 Russian Federation
  • A.G. Kakaulin Bashkir State Medical University. 3 Lenin str., Ufa Republic of Bashkortostan 450008 Russian Federation
  • I.I. Galimov Bashkir State Medical University. 3 Lenin str., Ufa Republic of Bashkortostan 450008 Russian Federation
DOI: https://doi.org/10.56871/RBR.2024.52.14.004
Keywords: COVID-19, pneumonia, comorbid diseases, risk of death, temporal trends

Abstract

Introduction. The main risk factors for adverse outcomes in patients with COVID-19 pneumonia are age and comorbidities. For accurate risk stratification, a comprehensive dynamic assessment of clinical, laboratory, and hemodynamic factors of patients is important. The aim of the study was to assess the risk factors for the development of a lethal outcome in patients with COVID-19 pneumonia with comorbid diseases based on the analysis of time trends in clinical and laboratory characteristics. Materials and Methods. A retrospective observational, multicenter study of 125 patients aged 18 to 75 years with laboratory-confirmed COVID-19 and/or ICD-10 U07.1 hospitalized with acute respiratory failure was conducted from March 2020 to May 2022. Demographic, clinical, and laboratory data of patients were recorded at the time of hospitalization and during the first 5 days of treatment. Results. In the analysis of operational characteristics and Kaplan–Meier survival curves, the age of patients >71 years, body mass index >29.8 kg/m2, and D-dimer levels >1600 ng/mL and procalcitonin >3.4 ng/mL were statistically significantly associated with the risk of death. For two parameters (D-dimer and procalcitonin levels), the prognostic value of the temporal trend was statistically significantly higher compared to their daily values. Conclusion. The increased risk of death in patients with COVID-19 pneumonia and comorbid diseases is associated with older age and high body mass index, but not with comorbid diseases. Temporal trends in D-dimer and procalcitonin have a greater predictive value compared to their daily values.

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Published
2024-07-31
How to Cite
Soloveychik, E., Lutfarakhmanov, I., Mironov, P., Kakaulin, A., & Galimov, I. (2024). RISK FACTORS FOR ADVERSE OUTCOMES OF COVID-19 PNEUMONIA IN PATIENTS INTENSIVE CARE UNIT WITH COMORBID DISEASES. Russian Biomedical Research, 9(2), 31-41. https://doi.org/10.56871/RBR.2024.52.14.004
Issue
Vol 9 No 2 (2024)
Section
Статьи

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