PATHOGENETIC MECHANISMS OF DEVELOPMENT OF BONE TISSUE PATHOLOGY IN CHRONIC GASTROINTESTINAL DISEASES
Abstract
The review describes the symptoms of damage to the skeletal system in celiac disease, chronic gastritis, the condition after gastrectomy and infl ammatory bowel diseases. The state of the vitamin D system and bone metabolism in chronic diseases of the digestive system, the mechanisms of the infl uence of vitamin D on the state of the intestinal mucosa, and risk factors contributing to pathological changes in bones in gastrointestinal diseases are presented. The review shows that in most cases, impaired bone mineral density in diseases of the digestive system is caused by impaired phosphorus-calcium metabolism, metabolism of the vitamin D system and impaired intestinal microbiocenosis, and specifi c mechanisms for each nosological form require further study.
References
Новикова В.П., Кузьмина Д.А., Гузеева О.Д. Хронический гастрит и патология костной ткани у детей. Врач-аспирант. 2011;47(4.1):248–254.
Бельмер С.В., Разумовский А.Ю., Хавкин А.И. и др. Болезни желудка и двенадцатиперстной кишки у детей. М.: Медпрактика-М; 2017.
Han T., Zhang Y., Qi B., Chen M., Sun K., Qin X., Yang B., Yin H., Xu A., Wei X., Zhu L. Clinical features and shared mechanisms of chronic gastritis and osteoporosis. Sci Rep. 2023;13(1):4991. DOI: 10.1038/s41598-023-31541-8.
Пигарова Е.А., Дзеранова Л.К., Яценко Д.А. Витамин D — вопросы всасывания и метаболизма в норме и при заболеваниях желудочно-кишечного тракта. Ожирение и метаболизм. 2022;19(1):123–33. DOI: 10.14341/omet12835. URL: https://applied-research.ru/ru/article/view?id=13566 (дата обращения: 02.01.2024).
Maurya V.K., Aggarwal M. Factors influencing the absorption of vitamin D in GIT: an overview. J Food Sci Technol. 2017;54(12):3753–3765. DOI: 10.1007/s13197-017-2840-0.
Shin C.S., Choi H.J., Kim M.J. et al. Prevalence and risk factors of osteoporosis in Korea: a community-based cohort study with lumbar spine and hip bone mineral density. Bone. 2010;47(2):378–387.
Слохова Н.К., Тотров И.Н. Регуляция кальциевого обмена и состояние костной ткани у больных с заболеваниями желудочно-кишечного тракта. Современные проблемы науки и образования. 2014;6. URL: https://science-education.ru/ru/article/view?id=16544 (дата обращения: 02.01.2024).
Szymczak-Tomczak A., Ratajczak A.E., Kaczmarek-Ryś M., Hryhorowicz S., Rychter A.M., Zawada A., Słomski R., Dobrowolska A., Krela-Kaźmierczak I. Pleiotropic Effects of Vitamin D in Patients with Inflammatory Bowel Diseases. J Clin Med. 2022;11(19):5715. DOI: 10.3390/jcm11195715.
Prevention and management of osteoporosis. World Health Organ Tech Rep Ser. 2003;921:1–164, back cover. PMID: 15293701.
Carmeliet G., Dermauw V., Bouillon R. Vitamin D Signaling in Calcium and Bone Homeostasis: A Delicate Balance. Best Pract. Res. Clin. Endocrinol. Metab. 2015;29:621–631. DOI: 10.1016/j.beem.2015.06.001.
Zhu W., Yan J., Zhi C., Zhou Q., Yuan X. 1,25(OH)2D3 deficiency-induced gut microbial dysbiosis degrades the colonic mucus barrier in Cyp27b1 knockout mouse model. Gut Pathog. 2019;11:8. DOI: 10.1186/s13099-019-0291-z.
Kühne H., Hause G., Grundmann S.M., Schutkowski A., Brandsch C., Stangl G.I. Vitamin D receptor knockout mice exhibit elongated intestinal microvilli and increased ezrin expression. Nutr. Res. 2016;36:184–192. DOI: 10.1016/j.nutres.2015.10.005.
Schäffler H., Herlemann D.P., Klinitzke P., Berlin P., Kreikemeyer B., Jaster R., Lamprecht G. Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn’s disease patients, but not in healthy controls. J. Dig. Dis. 2018;19:225–234. DOI: 10.1111/1751-2980.12591.
Fasano A. Zonulin, regulation of tight junctions, and autoimmune diseases. Ann. N.Y. Acad. Sci. 2012;1258:25–33. DOI: 10.1111/j.1749-6632.2012.06538.x.
Weber G., Heilborn J.D., Jimenez C.I.C., Hammarsjö A., Törmä H., Ståhle M. Vitamin D induces the antimicrobial protein hCAP18 in human skin. J. Investig. Dermatol. 2005;124:1080–1082. DOI: 10.1111/j.0022-202X.2005.23687.x.
Bals R., Wang X., Zasloff M., Wilson J.M. The peptide antibiotic LL37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc. Natl. Acad. Sci. USA. 1998;95:9541–9546. DOI: 10.1073/pnas.95.16.9541.
Gallo R.L., Kim K.J., Bernfield M., Kozak C.A., Zanetti M., Merluzzi L., Gennaro R. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J. Biol. Chem. 1997;272:13088–13093. DOI: 10.1074/jbc.272.20.13088.
Chun R.F., Liu P.T., Modlin R.L., Adams J.S., Hewison M. Impact of vitamin D on immune function: Lessons learned from genome-wide analysis. Front Physiol. 2014;5:151. DOI: 10.3389/fphys.2014.00151.
Bacchetta J., Zaritsky J.J., Sea J.L., Chun R., Lisse T.S., Zavala K., Nayak A., Wesseling-Perry K., Westerman M., Hollis B.W. et al. Suppression of iron-regulatory hepcidin by vitamin D. J. Am. Soc. Nephrol. 2014;25:564–572. DOI: 10.1681/ASN.2013040355.
Bikle D.D. Vitamin D Regulation of Immune Function. Curr. Osteoporos. Rep. 2022;20:186–193. DOI: 10.1007/s11914-022-00732-z.
Massironi S., Cavalcoli F., Zilli A., Del Gobbo A., Ciafardini C., Bernasconi S., Felicetta I., Conte D., Peracchi M. Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study. BMC Gastroenterol. 2018;18(1):172. DOI: 10.1186/s12876-018-0901-0.
Infantino C., Francavilla R., Vella A., Cenni S., Principi N., Strisciuglio C., Esposito S. Role of Vitamin D in Celiac Disease and Inflammatory Bowel Diseases. Nutrients. 2022;14(23):5154. DOI: 10.3390/nu14235154.
Шуматова Т.А., Коваленко Д.В., Приходченко Н.Г. Витамин D и заболевания кишечника. Международный журнал прикладных и фундаментальных исследований. 2023;8:24–28.
Eloranta J.J., Wenger C., Mwinyi J., Hiller C., Gubler C., Vavricka S.R., Fried M., Kullak-Ublick G.A., Swiss IBD Cohort Study Group Association of a Common Vitamin D-Binding Protein Polymorphism with Inflammatory Bowel Disease. Pharm. Genom. 2011;21:559–564. DOI: 10.1097/FPC.0b013e328348f70c.
Peterlik M. and Cross H.S. Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. European Journal of Clinical Nutrition. 2009;63:1377–1386.
Kang T.J., Jin S.H., Yeum C.E., Lee S.B., Kim C.H., Lee S.H., Kim K.H., Shin E.S., Chae G.T. Vitamin D Receptor Gene TaqI, BsmI and FokI Polymorphisms in Korean Patients with Tuberculosis. Immune Netw. 2011;11(5):253–257. DOI: 10.4110/in.2011.11.5.253.
Taymans S.E., Pack S., Pak E., Orban Z., Barsony J., Zhuang Z., Stratakis C.A. The human vitamin D receptor gene (VDR) is localized to region 12cen-q12 by fluorescent in situ hybridization and radiation hybrid mapping: genetic and physical VDR map. J Bone Miner Res. 1999;14(7):1163–1166. DOI: 10.1359/jbmr.1999.14.7.1163.
Valdivielso J.M., Fernandez E. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta. 2006; 371(1–2):1–12. DOI: 10.1016/j.cca.2006.02.016.
Baker A.R., McDonnell D.P., Hughes M. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proceedings of the National Academy of Sciences. 1998;85(10):3294–3298. DOI: 10.1073/pnas.85.10.3294.
Фомина Л.А. Роль кальцийрегулирующей системы в патогенезе и саногенезе язвенной болезни и коррекция ее сдвигов при лечении рецидива заболевания. Экспериментальная и клиническая гастроэнтерология 2016;134(10).
Храмцова С.Н. Оценка уровня кальция и фосфора в прогнозировании остеопении у детей и подростков. Общественное здоровье и профилактика заболеваний. 2007;2:47–50.
Щеплягина Л.А., Моисеева Т.Ю. Дефицит кальция — возможности пищевой коррекции у дошкольников. Consilium medicum. Педиатрия. 2007;1:80–83.
Хаустова Г.Г., Банина Т.В., Мухина Ю.Г., Щеплягина Л.С. Дефицит кальция и витамина Д при хронических заболеваниях желудка и тонкой кишки. Доктор.ру. 2008;1:14–18.
Лебеда В.Ф., Ясинский О.Р. Остеопатии у детей с хроническим гастродуоденитом. Педиатрия, акушерство и гинекология. 2000;2:29-31.
Шевченко С.Д., Ермак Т.А. Остеопенический синдром у детей и подростков, больных сколиозом. Российский педиатрический журн. 2005;1:21–24.
Elkin S.L., Fairney A., Burnett S. et al. Vertebral deformities and low bone mineral density in adults with cystic fibrosis: A cross-sectional study. Osteoporoses Int. 2001;12:366–72.
Leonard M.B. Glucocorticoid-induced osteoporosis in children: impact of the underlying disease. Pediatrics. 2007;119:166–S174.
Payne D., Ray D. Glucocorticoid receptor gene polymorphisms and susceptibility to rheumatoid arthritis. Clinical Endocrinology. 2007;67:342–345.
Schlienger R.G., Jick S.S., Meier C.R. Inhaled corticosteroids and the risk of fractures in children and adolescents. Pediatrics. 2004;114(2):469–473.
Targownik L.E., Lix L.M., Prior H.J. et al. Use of proton pump inhibitors and risk of osteoporosis-related fractures .Can. Med. Assoc. J. 2008;179:319–326.
Van Rossum E.F., Roks P.H., de Jong F.H. et al. Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms. Clinical Endocrinology (Oxf). 2004;61:573–581.
Ishino Y., Sugano K. Acid-suppressive strategy against gastroesophageal reflux diseases and non-erosive reflux diseases: the alternative of proton- pump inhibitors or H2 receptor antagonists. Nippon Rinsho. 2007;65(5):891–894.
Suzuki M., Suzuki H., Hibi T. Proton pump inhibitors and gastritis. J. Clin. Biochem. Nutr. 2008;42(2):71–75.
Tsirambidis J.V.E., Conwell D.L., Zuccaro G. Osteopenia in a patient with chronic pancreatitis. The American Journal of Gastroenterology. 2003;98(9):S164.
Yang Y., Lewis J., Epstein S. et al. Long-term proton pump inhibitor therapy and risk of hip fraction. J. Am. Med. Assoc. 2006;296:2947–2953.
Cijevschi C. at al. Osteoporosis in liver cirrhosis. Romanian J Gastroenterology 2005;4:337–41.
