RELATIONSHIP OF THE GESTATIONAL AGE OF A PREMATURE NEWBORN WITH A HEREDITARY PREDISPOSITION TO METABOLIC SYNDROME
Part I. Associations of molecular genetic predictors of arterial hypertension with the gestational age of premature newborns
Abstract
The aim of the study was to evaluate the frequency of allelic variants of the genes of predisposition to arterial hypertension in adults, depending on the gestation period of a premature newborn. The study design is prospective, controlled, single — center, non-randomized. Genomic DNA samples were studied in newborns with extremely low body weight (ELBW) and gestational age <28 weeks (n=95), premature newborns (NN) with gestational age >28 but <34 weeks (n=105), as well as a population sample of adults (n=100). For the analysis, loci with already known association with the development of arterial hypertension and coronary heart disease were selected: AGT (rs4762), AGTR1 (rs5186), ACE (Ins\Del), ADRB1 (rs1801253), ADD1 (rs4961), CYP11B2 (rs1799998), eNOS (rs1799983), eNOS (rs1549758), eNOS (rs2070744). The distribution of allele frequencies between the study groups was compared. Premature infants are signifi cantly more likely to carry the allele C of the AGT gene. In newborns with ELBW, we additionally found a more frequent occurrence of mutant alleles of the eNOS gene and the rare GG genotype in the ADRB1 gene. It is established that newborns with extremely low body weight, in contrast to the population of premature babies, are carriers of a greater number of risk alleles of genes predisposing to arterial hypertension.
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