RELATIONSHIP OF THE GESTATIONAL AGE OF A PREMATURE NEWBORN WITH A HEREDITARY PREDISPOSITION TO METABOLIC SYNDROME
Part II. Associations of molecular genetic predictors of overweight and type 2 diabetes mellitus with the gestational age of premature newborns
Abstract
The aim of the study was to evaluate the frequency of carrier allelic variants of polymorphic loci of genes predisposing to overweight and type 2 diabetes mellitus, depending on the gestation period of a premature newborn. The study design is prospective, controlled, single — center, non-randomized. Genomic DNA samples were studied in newborns with extremely low body weight (ELBW) and gestational age <28 weeks (n=95), premature newborns (РN) with gestational age >28 and <34 weeks (n=105), as well as a population sample of adults (n=100). For the analysis, we selected loci with a well — known association with the development of overweight and type 2 diabetes — ADRB2 (rs1042713) and (rs1042714), ADRB3 (rs4994), GNB3 (rs5443), PPARA (rs4253778), PPARD (rs2016520), TCF7L2_IVS3 (rs7903146) and TCF7L2_IVS4 (rs12255372), PPARGC1A (rs8192678), MTHFR (rs1801131), PPARG (rs1801282), MTNR1B (rs10830963), SIRT1 (rs7069102). The distribution of allele frequencies between the study groups was compared. PN are signifi cantly more likely to be carriers of the A allele and the AA genotype of the rs8192678 locus in the PPARGC1A gene. In newborns with ELBW, we additionally revealed a more frequent occurrence of the C allele and the CC genotype of the rs4253778 locus in the PPARA gene. It is established newborns with ELBW are more frequent carriers of rare allelic variants of genes predisposing to metabolic syndrome.
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