DISTINCTIVE FEATURES OF ALCOHOL-INDUCED REMODELING OF RAT LYMPH NODES PROXIMAL TO THE A. ILIOCOLICA
Abstract
Introduction. The term «fetal alcohol syndrome», which combines a set of changes in the offspring due to maternal alcohol consumption, has been known for a long time. However, the peculiarities of alcohol-induced transformation of lymphopoiesis organs are poorly described. The reason for this is the prevailing interest in the thymus and spleen, which explains the “neglect” of secondary structures of the immune system. Aim of the study — to investigate in an experiment the distinctive features of reorganization of lymph nodes located proximal to the a. iliocolica in infants whose parents abuse alcohol. Materials and methods. 30 newborn female rats were used to achieve the objective. The subjects were offspring of mongrel rats fed with 15% ethanol solution for 1 year before and during pregnancy. After termination of labor, animals were killed by decapitation. The corpses were dissected, during which the studied group of lymph nodes was removed. Then the obtained material was subjected to morphological analysis. Differences between the obtained data were considered reliable at p <0.05 by Student’s t-criterion. Results: the studied lymphopoiesis organs are polymorphic, differ in size and degree of differentiation. The predominant forms are oval and irregular. Regardless of their configuration, there are signs of relative immaturity — fatty infiltration, absence of cortical-brain differentiation, increased number of reticular cells. Conclusion. Prenatal alcohol intoxication leads to the development of significant disturbances in the structure of secondary organs of the immune system, which may subsequently predetermine the viability of the forming organism.
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