EXPERIMENTAL EVALUATION OF THE EFFECTIVENESS OF THE USE OF A GEL OF RARE-STITCHED ACRYLIC POLYMERS WITH NATURAL ANTIMICROBIAL PEPTIDES IN THE TREATMENT OF BORDERLINE SKIN BURNS

Abstract

The use of natural antimicrobial peptides with high antibacterial activity against most microorganisms, including antibioticresistant strains and polymicrobial associates (biological films), can be attributed to new methods of management of patients with burns. The experiment included 40 rats weighing 220–240 g, distributed into 4 groups depending on the treatment method:
control (without treatment), wet-drying dressings with an antiseptic solution (iodopyron), “Levomekol” ointment, gel of rare acrylic polymers with natural antimicrobial peptides. The results were evaluated on the 4th, 7th, 14th and 28th days. The gel of rare-stitched acrylic polymers with natural antimicrobial peptides had the highest efficiency: the area of the experimental wound by the 28th day was reduced to 0.3 ± 0.1 cm2 (12.6 times less than in the control group), the growth retardation zone of Staphylococcus aureus 209P was 34.9 mm, which is only 3.9 mm less than when using iodopyron, and the frequency of infectious complications and mortality were minimal — 10 and 5 %, respectively.