СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МЕХАНИЗМАХ АРТЕРИАЛЬНОГО ТРОМБОЗА. АРТЕРИАЛЬНЫЙ ТРОМБОЗ ПРИ НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИИ

I.A. Latypov; S.S. Purveev; M.S. Nekrasov; N.S. Dedanishvili; N.S. Tagirov

doi:10.56871/RBR.2023.85.16.008

I.A. Latypov Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
S.S. Purveev Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
M.S. Nekrasov Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
N.S. Dedanishvili Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
N.S. Tagirov Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100

DOI: https://doi.org/10.56871/RBR.2023.85.16.008

Keywords: venous thrombosis, arterial thrombosis, Virchow triad, COVID-19

Abstract

Complex mechanisms of thrombosis are traditionally regarded within the so called Virchov’s pathogenic thriade consisting of blood vessel injury + hypercoagulation + blood-flow slowing down. On spite of multiple additions and attempts at sophistications its essence remaiтs unchanged. However this threenominal scheme which is more or less applicable for explaining the pathogeny of venous thrombosis can be used in case of arterial ones only to a limited degree. Of late a different concept is under discussion namely that of arterial thriade consisting of different components: 1. Arterial stenosis and acceleration of bloodflow; 2. Platelets activation and their interaction with Von Willebrand factor (VWF); 3. Blood vessel wall injury. This composition of arterial thriade is more successfully explaining thrombosis mechanisms in case of arterial stenosis especially in case of atherosclerosis. Of late the attention is focused also at the association between new COVID-infection and increased risk of thrombosis. The new “arterial thriade” concept in addition to classical “Virchov’s thriade” or even that of “tetrade” will help pathophysiologists to better discriminate pathogenetical features of arterial thromboses vs the venous ones and for the clinical doctors to improve prophylaxis and treatment of these separate conditions.

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CONTEMPORARY CONCEPT OF ARTERIAL THROMBOSIS MECHANISMS. ARTERIAL THROMBOSIS IN CASE OF COVID INFECTION

Abstract

References

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