STATUS OF HEMOSTATIC SYSTEM IN MEN WITH UROLITHIASIS TREATED UNDER DURING COVID-19 PANDEMIC
Abstract
Introduction. Androgen replacement therapy has been shown to be effective in the treatment of patients with urolithiasis and androgen deficiency. The aim of the work was to find out whether androgen replacement therapy is applicable in the treatment of patients with androgen deficiency in the specific conditions of the COVID-19 pandemic with regard to its possible influence on the most important link in the pathogenesis of COVID-19 — blood coagulation. According to the results of hospital treatment of 199 men suffering from urolithiasis, it was found that androgen replacement therapy is not an obstacle for therapeutic measures aimed at persistent restriction of coagulation processes. Conclusion. In case of pandemic recurrence, androgen replacement therapy can be used in the treatment of urolithiasis.
References
Алексеев В.В., Алипов А.Н., Андреев В.А. и др. Медицинские лабораторные технологии. Т. 2. Москва: ГЭОТАР-Медиа; 2013. EDN: XPTADZ.
Васильев А.Г., Тагиров Н.С., Назаров Т.Х., Маджидов С.А., Ахмедов М.А. Современные аспекты этиологии и патогенеза мочекаменной болезни. Педиатр. 2014;5(3):101–109. DOI: 10.17816/PED53101-109.
Статистический анализ данных, моделирование и исследование вероятностных закономерностей. Новосибирск: Изд-во НГТУ, 2011.
Тагиров Н.С., Хайцев В., Назаров Т.Х., Гаджиев Н.К., Лихтшангоф А.З. Значение андрогенного дефицита в патогенезе уролитиаза: Экспериментальное и клиническое исследование. Клиническая патофизиология. 2016;2(1):107–112.
Тагиров Н.С. Оценка эффективности хирургического лечения мочекаменной болезни на фоне заместительной терапии препаратами тестостерона. Педиатр. 2019;10(2):46–54.
Тагиров Н.С. Патогенетическая коррекция метаболических нарушений и андрогенного дефицита в лечении больных уролитиазом (клинико-экспериментальное исследование). Автореф. дисс. … докт. мед. наук. СПб.; 2019.
Щербак С.Г., Сарана А.М., Анисенкова А.Ю., Вологжанин Д.А., Голота А.С., Камилова Т.А. Влияние сопутствующих заболеваний на тяжесть течения COVID-19. Университетский терапевтический вестник. 2024;6(1):26–48. DOI: 10.56871/UTJ.2024.35.52.003.
Abdel Raheem A., Alowidah I., Soliman M., Haresy M., Almozeni A., Althagafi S., Almousa M., Alturki M. Urolithiasis treatment options during COVID-19 pandemic: review of current recommendations and triage systems. Afr J Urol. 2020;26(1):75. DOI: 10.1186/s12301-020-00085-y.
Aboumohamed A., Gottlieb J., DeMasi M., Barry E., Sankin A., Watts K. Methodology for triage of urologic surgical cases in the setting of a pandemic. BMC Surg. 202;21(1):116. DOI: 10.1186/s12893-021-01067-9.
Aleebrahim-Dehkordi E., Soleiman-Dehkordi E., Saberianpour S., Hasanpour-Dehkordi A., Hasanpour Dehkordi A. Care and prevention during the COVID-19 pandemic quarantine: sedentary lifestyle and increased risk of kidney stones. Przegl Epidemiol. 2021;75(1):45–50. DOI: 10.32394/pe.75.04.
Anderson S., McNicholas D., Murphy C., Cheema I., McLornan L., Davis N., Quinlan M. The impact of COVID-19 on acute urinary stone presentations: a single-centre experience. Ir J Med Sci. 2022;191(1):45–49. DOI: 10.1007/s11845-021-02562-x.
Antonucci M., Recupero S.M., Marzio V. et al. The impact of COVID-19 outbreak on urolithiasis emergency department admissions, hospitalizations and clinical management in central Italy: a multicentric analysis. Actas Urol Esp (Engl Ed). 2020;44(9):611–616. DOI: 10.1016/j.acuro.2020.06.005. (In English, Spanish).
Chen G., Ren H. The development and application of a triage system for urolithiasis during COVID-19. World J Urol. 2022;40(2):577–583. DOI: 10.1007/s00345-021-03871-7.
Choi B.G., McLaughlin MA. Why men’s hearts break: cardiovascular effects of sex steroids. Endocrinol Metab Clin North Am. 2007;36(2):365–377. DOI: 10.1016/j.ecl.2007.03.011.
Gökce M.İ., Yin S., Sönmez M.G. et al. How does the COVID-19 pandemic affect the preoperative evaluation and anesthesia applied for urinary stones? EULIS eCORE-IAU multicenter collaborative cohort study. Urolithiasis. 2020;48(4):345–351. DOI: 10.1007/s00240-020-01193-8.
Gul M., Kaynar M., Yildiz M., Batur A.F., Akand M., Kilic O., Goktas S. The increased risk of complicated ureteral stones in the era of COVID-19 Pandemic. J Endourol. 2020;34(8):882–886. DOI: 10.1089/end.2020.0658.
Harke N.N., Radtke J.P., Hadaschik B.A .et al. To defer or not to defer? A German longitudinal multicentric assessment of clinical practice in urology during the COVID-19 pandemic. PLoS One. 2020;15(9):e0239027. DOI: 10.1371/journal.pone.0239027.
Karolczak K., Konieczna L., Kostka T., Witas P.J., Soltysik B., Baczek T., Watala C. Testosterone and dihydrotestosterone reduce platelet activation and reactivity in older men and women. Aging (Albany NY). 2018;10(5):902–929. DOI: 10.18632/aging.101438.
Nourian A., Uppaluri C., Chen M. et al. Comparison of management and outcomes of symptomatic urolithiasis during the COVID-19 pandemic to a comparative cohort. Urology. 2022;165:178–183. DOI: 10,1016/j.urology.2022.01.019.
Dehghani A., Shahisavandi M. et al. Pharmacotherapeutic approach toward urological medications and vaccination during COVID-19: a narrative review. Ther Adv Urol. 2021;13:17562872211046794. DOI: 10.1177/17562872211046794.
Valencia I., Lumpuy-Castillo J., Magalhaes G., Sánchez-Ferrer C.F., Lorenzo Ó., Peiró C. Mechanisms of endothelial activation, hypercoagulation and thrombosis in COVID-19: a link with diabetes mellitus. Cardiovasc Diabetol. 2024;23(1):75. DOI: 10.1186/s12933-023-02097-8.
Winkler U.H. Effects of androgens on haemostasis. Maturitas. 1996;24(3):147–155. DOI: 10.1016/s0378-5122(96)82004-4.
Wong V.K.F., Bhojani N., Bird V. et al. Quality of life of urolithiasis patients during the COVID-19 pandemic: a multi-institutional cross-sectional study. J Endourol. 2022;36(6):798–806. DOI: 10.1089/end.2021.0298.
Zitzmann M., Junker R., Kamischke A., Nieschlag E. Contraceptive steroids influence the hemostatic activation state in healthy men. J Androl. 2002;23(4):503–511.
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