LONG-TERM RESULTS OF COMBINED TREATMENT OF COMPLICATED GASTRIC CANCER USING INTRAOPERATIVE PHOTODYNAMIC THERAPY
Abstract
Stomach cancer remains one of the most common malignant tumors, ranking 4th in the male population (9.7%), 5th in the female population (5.2%). The five-year survival rate for thirdorder lymph nodes lesion is 5–26%, and the frequency of relapse after surgical treatment even with adjuvant therapy with invasion, T324 is 45%. The paper presents the long-term results of combined treatment of 121 patients with complicated forms of gastric cancer using intraoperative photodynamic therapy and without it. The patients were divided into two groups: the main group — 90 (74.3%) patients who underwent intraoperative PDT with irradiation of the lymph node dissection zone, and the control group, 31 (25.7%) patients who did not perform PDT. When comparing long-term treatment results: 6-month survival in the main group was 87.7% compared with 64% in the control group; one-year survival was 73.3% compared with 50%. The median overall survival of patients in the main group was 24 months, and in the control group — 12 months, while in the control group it was not achieved.
References
Каприн А.Д., Старвинский В.В., Шахзадова А.О. Состояние онкологической помощи населению России в 2019 году. М., 2020, 239 с.
Лацко Е.В. Современные аспекты диагностики и хирургического лечения рака желудка у пациентов пожилого и старческого возраста. Дисс. … канд. мед. наук. 2015, 162 с.
Бердов Б.А., Скоропад В.Ю., Цыб А.Ф., Мардынский Ю.С. Комбинированное лечение рака желудка с пред- и интраоперационным облучением. М., 2009, 256 с.
Филоненко Е.В., Каприн А.Д., Сулейманов Е.А. и др. Интраоперационная фотодинамическая терапия больных раком желудка. Biomedical Photonics. 2017;6(4):4-12. https://doi.org/10.24931/2413-9432-2017-6-4-4-12.
Карачун А.М., Самсонов Д.В. Непосредственные и отдаленные результаты мультиорганных резекций при местнораспространенном раке желудка. Российский медико-биологический вестник имени академика И.П. Павлова, №1, 2011, с. 103–108.
NCCN guidelines gastric cancer. Version 3.2023. 434 p.
Lee, Seung-Yol et al. Feasibility and Safety of Totally Laparoscopic Radical Gastrectomy for Advanced Gastric Cancer: Comparison with Early Gastric Cancer. Journal of Gastric Cancer 18 (2018): 152-160.
Jung, Kyoungwon. Park S. et al. Borrmann Type 4 Advanced Gastric Cancer: Focus on the Development of Scirrhous Gastric Cancer. Clinical Endoscopy 49 (2018): 336-345.
Shimoyama Y., Nishiwaki N. et al. Retospective multicenter study of photodynamic therapy for gastric cancer. Gastrointestinal endoscopy. Vol. 87, No. 6S : 2018, AB177.
