THE USE OF DIFFUSION TENSOR MRI IN THE DIAGNOSIS OF PERINATAL HYPOXIC-ISCHEMIC BRAIN DAMAGE IN PREMATURE NEWBORNS

  • V.S. Lvov Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100 http://orcid.org/0000-0002-2711-5321
  • D.O. Ivanov Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
  • A.V. Pozdnyakov Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
  • T.V. Melashenko Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
  • L.M. Makarov Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
  • O.F. Pozdnyakova Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
Keywords: hypoxic-ischemic brain injure, periventricular leico, periventricular leicomalacia, hypoxic-ischemic brain injure, peri-intraventricular hemorrhage, magnetic resonance imaging, diffusion tensor imaging

Abstract

Introduction. In the process of intrauterine development, the sensory pathways are myelinated earlier than the motor ones, which causes a higher sensitivity to hypoxia of these regions of the brain. The purpose of the study. To identify statistically significant differences in diffusion indices according to diffusion tensor MRI (DTI) data in premature infants with severe hypoxic-ischemic central nervous system damage in the form of periventricular leukomalacia (PVL) and peri-intraventricular hemorrhages (PIVH). Materials and methods. The study included 45 premature infants who were being cared for in the conditions of the perinatal center of St. Petersburg State Medical University. The gestational age of the patients at birth ranged from 25 to 30 weeks. Results. The study did not reveal a change in the diffusion indices in the area of the motor tract in children with PVL and PIVH compared with children with normal MRI. However, in children with no structural changes on MRI, higher FA values were noted in the posterior part of the PLIC (which reflects a higher organisation of the pathways at this level). At the same time, this pattern was not revealed in the groups of children with PVL and PIVH. Conclusion. Severe hypoxic-ischemic CNS damage in premature newborns aged 28-32 weeks of gestation is characterized by dysmyelination in the posterior parts of the hind legs of internal capsules containing sensitive pathways, which leads to a decrease in the index of fractional anisotropy determined by DTI. The FA index in the posterior part of PLIC can serve as a promising quantitative marker of severe hypoxic-ischemic brain injury.

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Published
2024-05-02
How to Cite
Lvov, V., Ivanov, D., Pozdnyakov, A., Melashenko, T., Makarov, L., & Pozdnyakova, O. (2024). THE USE OF DIFFUSION TENSOR MRI IN THE DIAGNOSIS OF PERINATAL HYPOXIC-ISCHEMIC BRAIN DAMAGE IN PREMATURE NEWBORNS. Visualization in Medicine, 6(1), 3-10. Retrieved from https://ojs3.gpmu.org/index.php/visual-med/article/view/5935
Issue
Vol 6 No 1 (2024)
Section
Статьи

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