СВЯЗЬ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ ПАРОДОНТА С СЕРДЕЧНО- СОСУДИСТЫМИ ЗАБОЛЕВАНИЯМИ АТЕРОСКЛЕРОТИЧЕСКОГО ГЕНЕЗА И АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ (ОБЗОР)

V.S. Vasilenko; I.N. Antonova; E.V. Matveeva; E.B. Karpovskaya; N.S. Kanavets; D.A. Shakhnazarov; N.A. Korelskaia

doi:10.56871/MTP.2023.61.37.001

V.S. Vasilenko Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
I.N. Antonova First Saint-Petersburg State Medical University named after I.P. Pavlov. Leo Tolstoy str., 6–8. Saint Petersburg, Russia, 197022
E.V. Matveeva First Saint-Petersburg State Medical University named after I.P. Pavlov. Leo Tolstoy str., 6–8. Saint Petersburg, Russia, 197022
E.B. Karpovskaya Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
N.S. Kanavets Saint Petersburg State Pediatric Medical University. Lithuania 2, Saint Petersburg, Russian Federation, 194100
D.A. Shakhnazarov North-Western Medical University named after I.I. Mechnikov. Kirochnaya 41, Saint Petersburg, Russian Federation, 191015
N.A. Korelskaia V.A. Almazov National Medical Research Center. Akkuratova str., 2, Saint Petersburg, Russian Federation, 197341

DOI: https://doi.org/10.56871/MTP.2023.61.37.001

Keywords: periodontal diseases, arterial hypertension, coronary heart disease, atherosclerotic cardiovascular diseases, causal relationships, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia

Abstract

Relevance. Considering the high prevalence of cardiovascular diseases and inflammatory periodontal diseases worldwide and the commonality of a number of pathogenetic mechanisms, as well as the statement of the American Academy of Pardontology published in 2012: “Observational studies confirm the link between periodontal diseases and atherosclerotic heart disease, regardless of known factors, … however, they do not confirm a causal relationship”, the study of the results of recent research on this topic is relevant. Purpose. Review of current research on the relationship between inflammatory periodontal diseases and cardiovascular diseases. Materials and methods. The materials were full-text, free publications on a given topic on PubMed and Google Scholar for 2019–2022. The chosen research direction is the relationship of periodontal diseases with atherosclerotic cardiovascular diseases and hypertension. The search was carried out by keywords: Periodontal Disease, ACVD, Atherosclerotic Cardiovascular Diseases, Hypertension. Results. In many epidemiological and cohort studies, a link has been established between
periodontal diseases and atherosclerotic cardiovascular diseases, but the results of randomized clinical studies on the effect of periodontal disease treatment on the progression of cardiovascular diseases are contradictory. The causal relationships in the conducted studies were not confirmed, since the relationships were presented only in the form of associations or correlations, which cannot certainly be considered causal. A causal relationship was established only between periodontitis and hypertension. Conclusions. Since the beneficial effect of periodontal therapy on the health of the cardiovascular system is obvious, the treatment of periodontal diseases can become a new approach to improving cardiovascular outcomes in patients with cardiovascular diseases of atherosclerotic genesis and arterial hypertension.

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ASSOCIATION OF INFLAMMATORY PERIODONTAL DISEASES WITH ATHEROSCLEROTIC CARDIOVASCULAR DISEASES AND ARTERIAL HYPERTENSION (REVIEW)

Abstract

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