INDICATORS OF LIPID METABOLISM AS PREDICTORS OF PROINFLAMMATORY CHANGES AND ENDOTHELIAL DYSFUNCTION IN YOUTHS WITH ABDOMINAL OBESITY
Abstract
Background. The study of lipid metabolism indicators and markers of endothelial dysfunction is necessary for a better understanding of the mechanisms of premature vascular aging
in adolescence. Aims: to determine the prevalence and structure of dyslipidemia, as well as its prognostic value in predicting structural and functional disorders of the vascular wall in young men
with abdominal obesity. Materials and methods. We examined 221 males aged 18−21 years with abdominal obesity (mean age 19.4±1.2 years). Results. Dyslipidemia was detected in 65.5% of young men with abdominal obesity. Structure of dyslipidemia: type IV — 68.4%; Type IIa — 21.1%; Type IIb — 10.5%. In the group of patients with dyslipidemia, the development of abdominal obesity was observed earlier than in the group without dyslipidemia (8.89±3.23 and 12.9±1.74 years; p <0.001). A strong inverse correlation was established between the age of onset of obesity and the levels of triglycerides (r=–0.74; p <0.05), total cholesterol (r=–0.73; p <0.05), low-density lipoproteins (r=–0.69; p<0.05) intermediate density lipoproteins (r=–0.52; p<0.05), and a direct relationship with high density lipoproteins (r=0.74; p <0.05). It has been proven that triglyceride levels are a strong predictor of a decrease in endothelium-dependent vasodilation (area under curve 0.97), an increase in vascular stiffness (area under curve 1.0), and an increase in circulating endothelial cells in the peripheral blood (area under curve 0.89). The strongest predictor of elevated high-sensitivity C-reactive protein is total cholesterol (area under curve 0.96). Conclusions. In young men with abdominal obesity, type IV dyslipidemia most often develops. Of all the indicators of the blood lipid spectrum, the most powerful predictor of structural and functional disorders of the vascular wall is the level of triglycerides. The strongest predictor of proinflammatory reactions is the level of total cholesterol.
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